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Estrogens as endogenous genotoxic agents--DNA adducts and mutations.
- E. Cavalieri, K. Frenkel, J. Liehr, E. Rogan, D. Roy
- Biology, ChemistryJournal of the National Cancer Institute…
- 1 July 2000
It is concluded that estrogens, including the natural hormones estradiol and estrone, must be considered genotoxic carcinogens on the basis of the evidence outlined in this chapter.
Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures.
- S. Burchiel, E. Cavalieri
- Environmental ScienceIARC monographs on the evaluation of carcinogenic…
Industrial processes that involve the pyrolysis or combustion of coal and the production and use of coal-derived products are major sources of PAHs and are the focus of this monograph.
Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators.
- E. Cavalieri, D. Stack, E. Rogan
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 30 September 1997
The hypothesis that CE-3,4-Q are endogenous tumor initiators is supported, supported by data that indicates that depurinating hydrocarbon-DNA adducts generate oncogenic mutations found in mouse skin papillomas.
Catechol estrogen quinones as initiators of breast and other human cancers: implications for biomarkers of susceptibility and cancer prevention.
Metabolism and DNA binding studies of 4-hydroxyestradiol and estradiol-3,4-quinone in vitro and in female ACI rat mammary gland in vivo.
Results demonstrate that the 4-CE are metabolized to CE-3,4-Q, which react with DNA to form primarily depurinating adducts, which can generate the critical mutations that initiate cancer.
Central role of radical cations in metabolic activation of polycyclic aromatic hydrocarbons.
It is demonstrated that formation of quinones and phenols occurs via an initial electron transfer from BP to P450 and subsequent transfer of oxygen from the iron-oxo complex of P450 to BP.
Genotoxic metabolites of estradiol in breast: potential mechanism of estradiol induced carcinogenesis
Molecular characteristics of catechol estrogen quinones in reactions with deoxyribonucleosides.
- D. Stack, J. Byun, M. Gross, E. Rogan, E. Cavalieri
- Chemistry, BiologyChemical research in toxicology
- 15 July 1996
Four estrogen-deoxyribonucleoside adducts were synthesized and provide insight into the type of DNA damage that can be caused by o-quinones of the catechol estrogens.
Unbalanced metabolism of endogenous estrogens in the etiology and prevention of human cancer
Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: potential biomarkers of susceptibility to cancer.
The level of catechol estrogen quinone conjugates in cases was three times that in controls, suggesting in the cases a higher probability for the quinones to react with DNA and generate mutations that may initiate cancer.