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Uridine receptor: discovery and its involvement in sleep mechanism.
It is suggested that uridine is released from steps of nucleic acid-nucleic protein biosynthesis (catabolism), and reaches the binding sites in the areas of the brain which regulate natural sleep as one of the triggering steps in inducing hypnotic activity. Expand
Region specific expression of NMDA receptor NR1 subunit mRNA in hypothalamus and pons following chronic morphine treatment.
Results suggest that changes in gene expression of the NRI subunit of the NMDA receptor are involved in the development of morphine tolerance and dependence. Expand
Effects of acute and continuous morphine administration on catecholamine-sensitive adenosine triphosphatase in mouse brain.
  • D. Desaiah, I. Ho
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental…
  • 1979
Results suggest that in mouse brain synaptosomes morphine may be interacting with ATPase at or near the catecholamine-active sites. Expand
Direct evidence for a role of glutamate in the expression of the opioid withdrawal syndrome.
The findings suggest that a rapid central release of glutamate may be a key factor in the expression of withdrawal signs from opioids, and this effect may be mediated by the NMDA subtype of glutamate receptors. Expand
Pharmacology of barbiturate tolerance/dependence: GABAA receptors and molecular aspects.
This minireview focuses on molecular and cellular aspects of the action of barbiturates and the possible mechanisms that contribute to development of tolerance to and dependence on barbiturate tolerance/dependence. Expand
A protein kinase inhibitor, H-7, inhibits the development of tolerance to opioid antinociception.
The results suggest that protein kinases may play an important role in the development of opioid tolerance. Expand
Proteomic analysis of phosphotyrosyl proteins in morphine-dependent rat brains.
The first available phosphotyrosine proteomic resources of morphine dependence were established using an animal model and illustrate the potential of proteomics as an effective technique for studying phosphorylation events of opioids dependence in brains. Expand
Differential effects of morphine and cocaine on locomotor activity and sensitization in μ-opioid receptor knockout mice
The results suggest that the expression of mu-opioid receptor may contribute to locomotor sensitization induced by morphine, but that mu-operative receptor does not play an important role in mediating sensitization to cocaine. Expand
Gender differences in the antinociceptive effect of tramadol, alone or in combination with gabapentin, in mice.
There was a lower ED(50) value of tramadol antinociception in males than in females, indicating that females were less sensitive to the drug, which may suggest a clinical significance of combined use of the two drugs. Expand
Cardiovascular toxicities of nandrolone and cocaine in spontaneously hypertensive rats.
The present study was designed to determine whether an animal model could be developed for investigation of the toxic responses to simultaneous administration of cocaine and an anabolic steroid, nandrolone decanoate, and to find out which group exhibited the lowest heart rate compared to other groups. Expand