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Region specific expression of NMDA receptor NR1 subunit mRNA in hypothalamus and pons following chronic morphine treatment.
The NMDA receptor has been implicated in opioid tolerance and physical dependence. Using in situ hybridization techniques, the effects of chronic morphine treatment on the expression of mRNAsExpand
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Uridine receptor: discovery and its involvement in sleep mechanism.
This review deals with the concept of sleep mechanism based on our uridine receptor theory. It is well established that uridine is one of the sleep-promoting substances, we have, therefore,Expand
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Direct evidence for a role of glutamate in the expression of the opioid withdrawal syndrome.
To investigate the role of glutamate in the expression of the withdrawal signs from opioids, rats were intracerebroventricularly (i.c.v.) infused continuously with morphine (a mu-opioid receptorExpand
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Pharmacology of barbiturate tolerance/dependence: GABAA receptors and molecular aspects.
Barbiturates are central nervous system depressants that are used as sedatives, hypnotics, anesthetics and anticonvulsants. However, prolonged use of the drugs produces physical dependence, and theExpand
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A protein kinase inhibitor, H-7, inhibits the development of tolerance to opioid antinociception.
To investigate the effect of a protein kinase inhibitor, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H-7), on the development of tolerance to antinociception induced by morphine (mu-opioidExpand
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Proteomic analysis of phosphotyrosyl proteins in morphine-dependent rat brains.
Morphine has been used as a potent analgesic, having a high propensity to induce tolerance and physical dependence following their repeated administration. Although the mechanisms that underlie theExpand
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Cardiovascular toxicities of nandrolone and cocaine in spontaneously hypertensive rats.
The outcome of concurrent abuse of cocaine and anabolic steroids is largely unknown and merits investigation. The present study was designed to determine whether an animal model could be developedExpand
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Effects of single or repeated dermal exposure to methyl parathion on behavior and blood cholinesterase activity in rats.
The effects of a single or repeated dermal administration of methyl parathion on motor function, learning and memory were investigated in adult female rats and correlated with blood cholinesteraseExpand
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Glutamate receptor antagonists block cocaine-induced convulsions and death
The involvement of excitatory amino acid (EAA) receptors in mediation of the toxic effects of cocaine was studied in male ICR mice. Cocaine HCl (90 mg/kg, IP) induced seizures in 95% and death withinExpand
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The interaction of morphine and γ-aminobutyric acid (GABA)ergic systems in anxiolytic behavior: using μ-opioid receptor knockout mice
We investigated the interaction of morphine and γ-aminobutyric acid (GABA)ergic systems in anxiolytic action using μ-opioid receptor knockout and wild-type female mice. An elevated plus-maze test wasExpand
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