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Proto-Oncogene Proteins c-raf

Known as: Proto-Oncogene Proteins c-raf [Chemical/Ingredient], c-raf Proteins, Kinase, raf-1 
A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. The c-raf Kinases are MAP kinase kinase kinases… 
National Institutes of Health

Related topics

Related topics

11 relations
In BloodOncogene Proteins v-rafProcess of secretionantagonists & inhibitors

Broader (2)

Protein-Serine-Threonine KinasesProto-Oncogene Proteins

Narrower (1)

proto-oncogene protein v-RAF1, pig

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Kinase suppressor of Ras transphosphorylates c-Raf-1.
2003
2003
Intravitreous anti-raf-1 kinase antisense oligonucleotide as an angioinhibitory agent in porcine preretinal neovascularization
Purpose. To test the efficacy of a synthetic antisense oligonucleotide inhibitor of an intracellular signal transduction protein… 
Highly Cited
2002
Highly Cited
2002
Identification of 14-3-3ζ as a Protein Kinase B/Akt Substrate*
Protein kinase B/Akt (PKB/Akt) is a member of the ACG kinase family, which also includes protein kinase C, that phosphorylates a… 
1999
1999
Interleukin-17 induces rapid tyrosine phosphorylation and activation of raf-1 kinase in human monocytic progenitor cell line U937.
Interleukin-17 is a T cell derived pro-inflammatory cytokine exhibiting multiple biological activities in a variety of cells and… 
1998
1998
Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast cancer cells
We have investigated whether the raf-1 kinase, a downstream mediator of both receptor tyrosine kinase and protein kinase C… 
1997
1997
Norepinephrine induces the raf-1 kinase/mitogen-activated protein kinase cascade through both alpha 1- and beta-adrenoceptors.
BACKGROUND Although norepinephrine induces cardiac hypertrophy by activating protein kinase A and C through beta- and alpha 1… 
1997
1997
Bcl-2 does not require Raf kinase activity for its death-protective function.
It has been widely accepted that the oncogene product bcl-2 protects mammalian cells from programmed cell death (apoptosis). The… 
Highly Cited
1995
Highly Cited
1995
Tumor necrosis factor (TNF)‐alpha activates c‐raf‐1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase.
TNF‐alpha mediates proliferation, functional activation and apoptotic death of cells depending upon its concentration and target… 
Highly Cited
1993
Highly Cited
1993
cAMP antagonizes p21ras‐directed activation of extracellular signal‐regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.
In fibroblasts, stimulation of receptor tyrosine kinases results in the activation of the extracellular signal‐regulated kinase 2… 
Highly Cited
1992
Highly Cited
1992
smg/rap1/Krev-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells.
smg/rap1A/Krev-1 p21 cDNA is known to inhibit v-Ki-ras p21-induced cell transformation in NIH3T3 cells, but the inhibitory… 
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