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Proto-Oncogene Proteins c-raf

Known as: Proto-Oncogene Proteins c-raf [Chemical/Ingredient], c-raf Proteins, Kinase, raf-1 
A ubiquitously expressed raf kinase subclass that plays an important role in SIGNAL TRANSDUCTION. The c-raf Kinases are MAP kinase kinase kinases… 
National Institutes of Health

Related topics

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11 relations
In BloodOncogene Proteins v-rafProcess of secretionantagonists & inhibitors

Broader (2)

Protein-Serine-Threonine KinasesProto-Oncogene Proteins

Narrower (1)

proto-oncogene protein v-RAF1, pig

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Raf-1 kinase mediates adenylyl cyclase sensitization by TNF-alpha in human airway smooth muscle cells.
Tumor necrosis factor (TNF)-alpha is a potent inflammatory cytokine implicated in the exacerbation of asthma. Chronic exposure to… 
2006
2006
Comparison of strategies targeting Raf‐1 mRNA in ovarian cancer
In this study, we characterize the uptake and specificity of a first‐generation Raf‐1 antisense oligonucleotide (ASO) (ISIS 5132… 
Review
2006
Review
2006
Raf kinases: Oncogenesis and drug discovery
Raf kinase signaling has been thoroughly investigated over the last 20 years. A‐Raf, B‐Raf and C‐Raf, the 3 mammalian members of… 
2004
2004
Induction of raf-1 protein immunoreactivity in guinea pig hippocampal slices during the in vitro maintenance
SummaryThe cellular raf-1 protooncogene encodes a cytoplasmic serine/threonine protein kinase; raf-1 is expressed not only in… 
1997
1997
The proto-oncogene Crk-II enhances apoptosis by a Ras-dependent, Raf-1/MAP kinase-independent pathway.
Human embryonic kidney 293 cells and 293 cells overexpressing different amounts of the adaptor protein Crk-II (ranging from 3- to… 
1997
1997
Bcl-2 does not require Raf kinase activity for its death-protective function.
It has been widely accepted that the oncogene product bcl-2 protects mammalian cells from programmed cell death (apoptosis). The… 
1997
1997
Characterization of the structural difference between active and inactive forms of the Ras protein by chemical modification followed by mass spectrometric peptide mapping.
Ras is one of the guanosine triphosphate (GTP) binding proteins that plays a significant role in signaling events of cell growth… 
1994
1994
smg/rap1/Krev-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells
1993
1993
Immunohistochemical detection of raf protein kinase in cerebral cortical areas of adult guinea pigs and rats
Highly Cited
1992
Highly Cited
1992
smg/rap1/Krev-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-Ki-ras p21 but not from c-raf-1 kinase in NIH3T3 cells.
smg/rap1A/Krev-1 p21 cDNA is known to inhibit v-Ki-ras p21-induced cell transformation in NIH3T3 cells, but the inhibitory… 
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