ARRIVE 2.0 and the British Journal of Pharmacology: Updated guidance for 2020
- Elliot Lilley, S. Stanford, A. Ahluwalia
- MedicineBritish Journal of Pharmacology
- 14 July 2020
The BJP has been and remains an active advocate of the ARRIVE guidelines and the Editor in Chief of the BJP is a member of the new team that was assembled, which triggered a reappraisal of the guidelines led by the NC3Rs who, in 2018, established a new, international Working Group to review and update the ARrIVE guidelines.
The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy
- H. Stedman, H. Sweeney, A. Kelly
- Medicine, BiologyNature
- 8 August 1991
It is proposed that dystrophin deficiency alters the threshold for work-induced injury and provides a quantitative framework for studying the pathogenesis of dystrophy and extend the application of the mdx mouse as an animal model.
Asthma
- R. Panettieri
- MedicineAnnals of Internal Medicine
- 17 March 1894
Clinicians should consider the diagnosis of asthma in all adults with chronic cough, especially if cough is nocturnal, seasonal, or related to the workplace or a specific activity, given the improvement in air quality in the United States and the availability of new pharmacologic therapies.
Asthma outcomes: biomarkers.
- S. Szefler, S. Wenzel, M. Minnicozzi
- Medicine, BiologyJournal of Allergy and Clinical Immunology
- 1 March 2012
Sphingosine 1‐phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma
- A. Ammit, A. Hastie, R. Panettieri
- BiologyThe FASEB Journal
- 1 May 2001
These studies are the first to associate sphingosine 1‐phosphate with airway inflammation and to identify SPP as an effective regulator of ASM growth, contraction and synthetic functions.
CD38‐cyclic ADP‐ribose‐mediated Ca2+ signaling contributes to airway smooth muscle hyperresponsiveness
- D. Deshpande, T. Walseth, R. Panettieri, M. Kannan
- BiologyThe FASEB Journal
- 1 March 2003
A role for CD38‐cADPR signaling is demonstrated in a model of inflammatory airway disease and the magnitude of inhibition correlating with the level of CD38 is demonstrated.
Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells.
- J. Laporte, P. Moore, S. Shore
- BiologyAmerican Journal of Respiratory and Critical Care…
- 1 July 2001
This hypothesis that IL-13 and IL-4 have direct effects on cultured airway smooth muscle cells (HASM) is proposed to contribute at least in part to the airway narrowing observed in patients with asthma.
IL‐13 enhances agonist‐evoked calcium signals and contractile responses in airway smooth muscle
- O. Tliba, D. Deshpande, Y. Amrani
- BiologyBritish Journal of Pharmacology
- 1 December 2003
It is demonstrated that IL‐13 may promote BHR by directly modulating ASM contractility, an effect that may be due to enhanced G protein‐coupled receptor (GPCR)‐associated calcium signaling.
Selected contribution: time course and heterogeneity of contractile responses in cultured human airway smooth muscle cells.
- B. Fabry, G. Maksym, J. Fredberg
- BiologyJournal of applied physiology
- 1 August 2001
It is concluded that HASM cells in culture exhibit a clear, although heterogeneous, response to contractile and relaxing agonists and express the essential mechanical features characteristic of the contractile response observed at the tissue level.
Effect of IL-1 beta on responses of cultured human airway smooth muscle cells to bronchodilator agonists.
- S. Shore, J. Laporte, I. Hall, E. Hardy, R. Panettieri
- BiologyAmerican Journal of Respiratory Cell and…
- 1 June 1997
IL-1 beta causes a concentration- and time-dependent decrease in responses of cultured human airway smooth muscle cells to ISO and is consistent with the hypothesis that the effects of IL-1 Beta are mediated by uncoupling of beta-receptors from Gs-induced activation of adenylyl cyclase.
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