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Proto-Oncogene Proteins c-akt

Known as: Related to A and C-Protein, Protein Kinase B, c-akt Protein 
Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha, Beta and Gamma) of cytoplasmic serine/threonine enzymes that… 
National Institutes of Health

Related topics

Related topics

18 relations
7-hydroxystaurosporineAKT1 geneIn BloodProcess of secretion

Narrower (5)

AKT2 protein, humanAKT3 protein, humanRAC-Alpha Serine/Threonine Kinaseprotein kinase B gamma

Papers overview

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Highly Cited
2011
Highly Cited
2011
Collagen I regulates the self‐renewal of mouse embryonic stem cells through α2β1 integrin‐ and DDR1‐dependent Bmi‐1
Adhesion of cells to extracellular matrix (ECM) influences vital aspects of anchorage‐dependent cell behavior including survival… 
Highly Cited
2005
Highly Cited
2005
Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation
The inhibitor of apoptosis protein (IAP) survivin is overexpressed in many tumors but is absent in most normal adult tissues. We… 
Highly Cited
2003
Highly Cited
2003
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather…
Effects of the PI-3 kinase inhibitor LY294002 (LY) have been examined in relation to responses of human leukemia cells to histone… 
Review
2003
Review
2003
Akt is a molecular target for signal transduction therapy in brain ischemic insult.
Growth factors including insulin-like growth factor-1 (IGF-1) promote cell survival in ischemic brain injury. Stimulation of IGF… 
Highly Cited
2003
Highly Cited
2003
Fluid shear stress inhibits TNF‐α‐induced apoptosis in osteoblasts: A role for fluid shear stress‐induced activation of PI3‐kinase and inhibition of caspase‐3
In bone, a large proportion of osteoblasts, the cells responsible for deposition of new bone, normally undergo programmed cell… 
Highly Cited
2002
Highly Cited
2002
Ceramide and Reactive Oxygen Species Generated by H2O2 Induce Caspase-3-independent Degradation of Akt/Protein Kinase B*
This study was designed to elucidate the mechanisms leading to down-regulation of the Akt/protein kinase B (PKB) survival pathway… 
Highly Cited
2002
Highly Cited
2002
Regulation of TRAIL Expression by the Phosphatidylinositol 3-Kinase/Akt/GSK-3 Pathway in Human Colon Cancer Cells*
The intestinal mucosa is a rapidly-renewing tissue characterized by cell proliferation, differentiation, and eventual apoptosis… 
Highly Cited
2001
Highly Cited
2001
The common Arg972 polymorphism in insulin receptor substrate‐1 causes apoptosis of human pancreatic islets
Molecular scanning of human IRS‐1 gene revealed a common polymorphism causing Gly →Arg972 change. Diabetic and pre‐diabetic… 
Highly Cited
1998
Highly Cited
1998
A Novel Integrin-activated Pathway Forms PKB/Akt- stimulatory Phosphatidylinositol 3,4-Bisphosphate via Phosphatidylinositol 3-Phosphate in Platelets*
The aggregation of human platelets is an important physiological hemostatic event contingent upon receptor-dependent activation… 
Highly Cited
1989
Highly Cited
1989
A new methodology for the optimal design and production schedule of multipurpose batch plants
Presentation d'une procedure algorithmique determinant simultanement le programme optimal de production et les tailles des… 
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