Proto-Oncogene Proteins c-akt

Known as: Related to A and C-Protein, Protein Kinase B, c-akt Protein 
Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha, Beta and Gamma) of cytoplasmic serine/threonine enzymes that… (More)

Topic mentions per year

Topic mentions per year

1963-2017
02000400019632017

Papers overview

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Review
2016
Review
2016
Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute… (More)
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Review
2016
Review
2016
Aging is a natural process characterized by the declining ability of the different organs and tissues to respond to stress… (More)
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Review
2016
Review
2016
Mutation of the KRAS oncogene in pancreatic cancer is responsible for permanent activation of the P21 RAS protein and the cascade… (More)
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Highly Cited
2005
Highly Cited
2005
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires… (More)
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Highly Cited
2002
Highly Cited
2002
The S/T-protein kinases activated by phosphoinositide 3-kinase (PI3K) regulate a myriad of cellular processes. Here, we show that… (More)
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Highly Cited
1999
Highly Cited
1999
The mechanisms of cell proliferation and transformation are intrinsically linked to the process of apoptosis: the default of… (More)
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Highly Cited
1999
Highly Cited
1999
Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/ threonine kinase Akt… (More)
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Highly Cited
1997
Highly Cited
1997
Growth factors can promote cell survival by activating the phosphatidylinositide-3'-OH kinase and its downstream target, the… (More)
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Highly Cited
1997
Highly Cited
1997
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF… (More)
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Highly Cited
1995
Highly Cited
1995
The serine/threonine protein kinase encoded by the Akt proto-oncogene is catalytically inactive in serum-starved primary and… (More)
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