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Proto-Oncogene Proteins c-akt

Known as: Related to A and C-Protein, Protein Kinase B, c-akt Protein 
Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha, Beta and Gamma) of cytoplasmic serine/threonine enzymes that… Expand
National Institutes of Health

Related topics

Related topics

18 relations
7-hydroxystaurosporineAKT1 geneIn BloodProcess of secretion
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Narrower (5)

AKT2 protein, humanAKT3 protein, humanRAC-Alpha Serine/Threonine Kinaseprotein kinase B gamma
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Targeting the PI3K pathway in cancer: are we making headway?
The PI3K–AKT–mTOR pathway is one of the most frequently dysregulated pathways in cancer and, consequently, more than 40 compounds… Expand
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Review
2018
Review
2018
Function of the c-Met receptor tyrosine kinase in carcinogenesis and associated therapeutic opportunities
Abstractc-Met is a receptor tyrosine kinase belonging to the MET (MNNG HOS transforming gene) family, and is expressed on the… Expand
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Review
2018
Review
2018
Targeting the PI3K/AKT/mTOR pathway in triple-negative breast cancer: a review
PurposeTriple-negative breast cancer (TNBC) accounts for approximately 20% of breast cancer cases. Although there have been… Expand
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Review
2018
Review
2018
Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases.
Reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as important second messengers within the… Expand
Is this relevant?
Review
2018
Review
2018
PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux.
Cancer therapies will increasingly be utilized in combination to treat advanced malignancies so as to increase their long-term… Expand
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Review
2018
Review
2018
The regulation of autophagy by calcium signals: Do we have a consensus?
Macroautophagy (hereafter called 'autophagy') is a cellular process for degrading and recycling cellular constituents, and for… Expand
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Review
2018
Review
2018
Apigenin: A dietary flavonoid with diverse anticancer properties.
Apigenin is a natural flavonoid found in several dietary plant foods such as vegetables and fruits. A large number of studies… Expand
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Review
2017
Review
2017
mTORC1 as the main gateway to autophagy
Cells and organisms must coordinate their metabolic activity with changes in their environment to ensure their growth only when… Expand
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Review
2017
Review
2017
Acute lymphoblastic leukemia: a comprehensive review and 2017 update
Acute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults, with an incidence of over 6500 cases per… Expand
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Review
2016
Review
2016
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination.
Phosphatidylinositide 3 kinases (PI3Ks) and their downstream mediators AKT and mammalian target of rapamycin (mTOR) constitute… Expand
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