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Proto-Oncogene Proteins c-akt

Known as: Related to A and C-Protein, Protein Kinase B, c-akt Protein 
Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha, Beta and Gamma) of cytoplasmic serine/threonine enzymes that… 
National Institutes of Health

Related topics

Related topics

18 relations
7-hydroxystaurosporineAKT1 geneIn BloodProcess of secretion

Narrower (5)

AKT2 protein, humanAKT3 protein, humanRAC-Alpha Serine/Threonine Kinaseprotein kinase B gamma

Papers overview

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Highly Cited
2009
Highly Cited
2009
Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size.
Myostatin is a negative regulator of skeletal muscle size, previously shown to inhibit muscle cell differentiation. Myostatin… 
Highly Cited
2005
Highly Cited
2005
Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial–mesenchymal transition
The Akt family of kinases are activated by growth factors and regulate pleiotropic cellular activities. In this study, we provide… 
Highly Cited
2002
Highly Cited
2002
Activation of Rac and Cdc42 Video Imaged by Fluorescent Resonance Energy Transfer-Based Single-Molecule Probes in the Membrane of Living Cells
ABSTRACT Rho family G proteins, including Rac and Cdc42, regulate a variety of cellular functions such as morphology, motility… 
Review
2002
Review
2002
PKB Binding Proteins Getting in on the Akt
Highly Cited
2001
Highly Cited
2001
Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice*
The serine-threonine kinase Akt, also known as protein kinase B (PKB), is an important effector for phosphatidylinositol 3-kinase… 
Highly Cited
2000
Highly Cited
2000
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.
The microbially derived antiproliferative agent rapamycin inhibits cell growth by interfering with the signaling functions of the… 
Highly Cited
1999
Highly Cited
1999
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt.
Extracellular signals often result in simultaneous activation of both the Raf-MEK-ERK and PI3K-Akt pathways (where ERK is… 
Highly Cited
1998
Highly Cited
1998
Phosphatidylinositol 3-Kinase and Akt Protein Kinase Are Necessary and Sufficient for the Survival of Nerve Growth Factor-Dependent Sympathetic Neurons
Recent studies have suggested a role for phosphatidylinositol (PI) 3-kinase in cell survival, including the survival of neurons… 
Highly Cited
1997
Highly Cited
1997
Matrix adhesion and Ras transformation both activate a phosphoinositide 3‐OH kinase and protein kinase B/Akt cellular survival pathway
Upon detachment from the extracellular matrix, epithelial cells enter into programmed cell death, a phenomenon known as anoikis… 
Highly Cited
1991
Highly Cited
1991
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region.
The v-akt oncogene codes for a 105-kilodalton fusion phosphoprotein containing Gag sequences at its amino terminus. Sequence… 
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