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Proto-Oncogene Protein pp60 (c-src)

Known as: Protein src, Proto-Oncogene, pp60 c src, src Proto Oncogene Product 
Membrane-associated tyrosine-specific kinases encoded by the c-src genes. They have an important role in cellular growth control. Truncation of… 
National Institutes of Health

Related topics

Related topics

13 relations
In BloodProcess of secretionSRC geneantagonists & inhibitors

Narrower (4)

MATK protein, humanMatk protein, mouseProto-Oncogene Tyrosine-Protein Kinase Src, humanlyn protein-tyrosine kinase

Papers overview

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Highly Cited
2000
Highly Cited
2000
A MAP Kinase-Signaling Pathway Mediates Neurite Outgrowth on L1 and Requires Src-Dependent Endocytosis
The neural cell adhesion molecule L1 mediates the axon outgrowth, adhesion, and fasciculation necessary for proper development of… 
Highly Cited
1999
Highly Cited
1999
Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors
Tumors that overexpress HER-2/neu receptor or exhibit enhanced EGFR signaling have been reported to possess constitutively… 
Highly Cited
1999
Highly Cited
1999
pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding…
The cyclin D1 gene is overexpressed in breast tumors and encodes a regulatory subunit of cyclin-dependent kinases that… 
Highly Cited
1999
Highly Cited
1999
Adhesion-dependent degranulation of neutrophils requires the Src family kinases Fgr and Hck.
Polymorphonuclear neutrophils (PMN) adherent to integrin ligands respond to inflammatory mediators by reorganizing their… 
Highly Cited
1999
Highly Cited
1999
Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases.
Tyrosine phosphorylation of focal adhesion kinase (FAK) creates a high-affinity binding site for the src homology 2 domain of the… 
Review
1998
Review
1998
SCID Mouse Models of Human Stem Cell Engraftment
The discovery of the severe combined immunodeficiency (scid) mouse mutation has provided a tool for establishment of small animal… 
Highly Cited
1998
Highly Cited
1998
Protein-tyrosine Phosphatase α Regulates Src Family Kinases and Alters Cell-Substratum Adhesion*
The roles of protein-tyrosine phosphatases (PTPs) in processes such as cell growth and adhesion are poorly understood. To explore… 
Highly Cited
1995
Highly Cited
1995
Proline-rich sequences that bind to Src homology 3 domains with individual specificities.
To study the binding specificity of Src homology 3 (SH3) domains, we have screened a mouse embryonic expression library for… 
Highly Cited
1995
Highly Cited
1995
Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal.
Src homology 2 (SH2) domain-mediated interactions with phosphotyrosine residues are critical in many intracellular signal… 
Highly Cited
1988
Highly Cited
1988
Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity
We have shown previously that pp60c-src is a substrate for protein kinase C in vivo and that the target of protein kinase C… 
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