Proto-Oncogene Tyrosine-Protein Kinase Src, human
Semantic Scholar uses AI to extract papers important to this topic.
The proto-oncogene c-src is rarely mutated in human cancers, and when overexpressed in normal cells is non- or weakly oncogenic… Expand Src kinase activity was found to protect endothelial cells from apoptosis during vascular endothelial growth factor (VEGF)-, but… Expand ANGIOGENESIS, the formation of new microvasculature by capillary sprouting, is crucial for tumour development1. Hypoxic regions… Expand Extracellular matrix controls capillary endothelial cell sensitivity to soluble mitogens by binding integrin receptors and… Expand Signaling by tyrosine kinase receptors is mediated by selective interactions between individual Src homology 2 (SH2) domains of… Expand Targeted disruption of the c-src proto-oncogene in mice has shown that src expression is required for normal bone resorption… Expand Affinity-purified bovine brain phosphatidylinositol 3-kinase (PI3-kinase) contains two major proteins of 85 and 110 kd. Amino… Expand Phospholipase C gamma 1 (PLC gamma 1) and p21ras guanosine triphosphatase (GTPase) activating protein (GAP) bind to and are… Expand We have purified the 36 and 63 kd cellular proteins known to associate with polyomavirus middle and small tumor (T) antigens and… Expand Polyoma middle-T antigen is required for viral transformation of cultured cells and for tumorigenesis in animals. Like many other… Expand