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Proto-Oncogene Tyrosine-Protein Kinase Src, human

Known as: pp60c-src, p60-SRC, p60src 
Proto-oncogene tyrosine-protein kinase Src (536 aa, ~60 kDa) is encoded by the human SRC gene. This protein is involved in both receptor-mediated… Expand
National Institutes of Health

Papers overview

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Review
2004
Review
2004
The proto-oncogene c-src is rarely mutated in human cancers, and when overexpressed in normal cells is non- or weakly oncogenic… Expand
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Review
2001
Review
2001
As one of the most extensively studied protein hormones, insulin and its receptor have been known to play key roles in a variety… Expand
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Highly Cited
1999
Highly Cited
1999
Src kinase activity was found to protect endothelial cells from apoptosis during vascular endothelial growth factor (VEGF)-, but… Expand
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Highly Cited
1995
Highly Cited
1995
ANGIOGENESIS, the formation of new microvasculature by capillary sprouting, is crucial for tumour development1. Hypoxic regions… Expand
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Highly Cited
1995
Highly Cited
1995
Extracellular matrix controls capillary endothelial cell sensitivity to soluble mitogens by binding integrin receptors and… Expand
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Highly Cited
1994
Highly Cited
1994
Signaling by tyrosine kinase receptors is mediated by selective interactions between individual Src homology 2 (SH2) domains of… Expand
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Highly Cited
1992
Highly Cited
1992
Targeted disruption of the c-src proto-oncogene in mice has shown that src expression is required for normal bone resorption… Expand
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Highly Cited
1990
Highly Cited
1990
Phospholipase C gamma 1 (PLC gamma 1) and p21ras guanosine triphosphatase (GTPase) activating protein (GAP) bind to and are… Expand
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Highly Cited
1990
Highly Cited
1990
We have purified the 36 and 63 kd cellular proteins known to associate with polyomavirus middle and small tumor (T) antigens and… Expand
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Highly Cited
1985
Highly Cited
1985
Polyoma middle-T antigen is required for viral transformation of cultured cells and for tumorigenesis in animals. Like many other… Expand
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