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SRC gene

Known as: AVIAN SARCOMA VIRUS, SRC, ONCOGENE SRC 
This gene is involved in apoptosis, hormonogenesis, focal adhesion and the formation of intercellular junctions.
National Institutes of Health

Related topics

Related topics

19 relations
Cell Differentiation processCell ProliferationGenes, srcHomo sapiens

Narrower (2)

FYN geneSRC wt Allele

Broader (1)

Oncogenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Regulation of Connexin43-Protein Binding in Astrocytes in Response to Chemical Ischemia/Hypoxia*
Connexin-protein interactions are believed to be critical for the regulation of gap junctional intercellular communication and… 
Review
1998
Review
1998
The many faces of Src: multiple functions of a prototypical tyrosine kinase
c-src was first isolated as the normal cellular homologue of v-src, the transforming gene of Rous Sarcoma virus (). As the first… 
Review
1993
Review
1993
Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins
H~ technology of gene targeting is still in its infancy, but one astonishing theme is being seen over and over. Disruption of a… 
Highly Cited
1991
Highly Cited
1991
Selective binding of activated pp60c-src by an immobilized synthetic phosphopeptide modeled on the carboxyl terminus of pp60c-src.
Phosphorylation of the carboxyl terminus of pp60c-src, the product of the c-src protooncogene, at Tyr-527 suppresses its tyrosine… 
Highly Cited
1991
Highly Cited
1991
Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed…
The monoclonal antibody 2B12 is directed toward p120, a 120-kDa cellular protein originally identified as a protein tyrosine… 
Highly Cited
1990
Highly Cited
1990
Synaptophysin: a substrate for the protein tyrosine kinase pp60c-src in intact synaptic vesicles.
Expression of pp60c-src, the first well defined proto-oncogene product, is developmentally regulated and tissue-specific, with… 
Highly Cited
1989
Highly Cited
1989
pp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src
In previous studies examining the potential role of pp60c-src in cellular proliferation, we demonstrated that C3H10T1/2 murine… 
Review
1987
Review
1987
The covalent modification of eukaryotic proteins with lipid
surprisingly large number of proteins in eukaryotic ceils are now known to contain covalently bound lipid. Several cell surface… 
Highly Cited
1987
Highly Cited
1987
The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA
A cellular src (c-src) cDNA clone was isolated from a chicken embryonic brain cDNA library and characterized by DNA sequence… 
Highly Cited
1985
Highly Cited
1985
Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src
We have previously found that Rous sarcoma virus variants in which the viral src (v-src) gene is replaced by the cellular src (c… 
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