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Oncogenes

Known as: Oncogene, Cancer-Promoting Gene, Genes, Transforming 
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of… 
National Institutes of Health

Related topics

Related topics

48 relations
BCR/ABL1 Fusion Protein with ABL1 NP_005148.2:p.T315ICCDC6/RET Fusion ProteinCancer Promoting GenesCarcinogens

Narrower (11)

FOS Family GenesMYC Family GenesREL geneSRC gene

Broader (2)

GenesMutation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1990
Highly Cited
1990
Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma.
Previous studies have implicated the rasHa oncogene in the initiation of skin carcinogenesis and the fos oncogene in malignant… 
Highly Cited
1988
Highly Cited
1988
Expression of Ha-ras oncogene products in human neuroblastomas and the significant correlation with a patient's prognosis.
Neuroblastomas represent a spectrum of diseases categorized by histological subtypes, age of the patient, and extent of tumor… 
Highly Cited
1987
Highly Cited
1987
Construction of a novel oncogene based on synthetic sequences encoding epidermal growth factor.
The autocrine model postulates that constitutive release of a mitogenic growth factor can lead to uncontrolled proliferation and… 
1987
1987
Mapping of the oncogenes Myc, Sis, and int-1 to the distal part of mouse chromosome 15.
Two proto-oncogenes, Myc and Sis, as well as a putative mouse oncogene, int-1, were localized by in situ hybridization to the… 
Highly Cited
1986
Highly Cited
1986
Increased levels of mitochondrial gene expression in rat fibroblast cells immortalized or transformed by viral and cellular oncogenes.
Steady‐state levels of the mitochondrial (mt) mRNA encoding subunit II of cytochrome oxidase (COII) were increased 5‐10 fold in… 
Review
1985
Review
1985
Expression of N-myc in teratocarcinoma stem cells and mouse embryos
The N-myc gene, which is distantly related to the proto-oncogene c-myc, was first detected as an amplified sequence in human… 
Review
1985
Review
1985
NIH conference. Molecular genetic analysis of human lymphoid neoplasms. Immunoglobulin genes and the c-myc oncogene.
Immunoglobulin genes responsible for individual antibodies are organized as discontinuous DNA segments in their germline form. As… 
Highly Cited
1985
Highly Cited
1985
Regulation of a collagen gene promoter by the product of viral mos oncogene
Oncogenic transformation of cells produces important changes in the biosynthetic pattern of certain cellular proteins1–6. For… 
Highly Cited
1983
Highly Cited
1983
Oncogene from human EJ bladder carcinoma is located on the short arm of chromosome 11.
The human cellular homolog of the transforming DNA sequence isolated from the bladder carcinoma cell line EJ was localized on the… 
1981
1981
Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses.
Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA… 
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