Oncogenes

Known as: Oncogene, Cancer-Promoting Gene, Genes, Transforming 
Genes whose gain-of-function alterations lead to NEOPLASTIC CELL TRANSFORMATION. They include, for example, genes for activators or stimulators of… (More)

Topic mentions per year

Topic mentions per year

1954-2017
01000200019542016

Papers overview

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Review
2016
Review
2016
The 2013 discovery of Telomerase reverse transcriptase (TERT) promoter mutations chr5, 1,295,228 C>T (C228T) and 1,295,250 C>T… (More)
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Highly Cited
2009
Highly Cited
2009
Cancer is a complex collection of distinct genetic diseases united by common hallmarks. Here, we expand upon the classic… (More)
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Highly Cited
2009
Highly Cited
2009
In cancer cells, genetic alterations can activate proto-oncogenes, thereby contributing to tumorigenesis. However, the protein… (More)
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Highly Cited
2006
Highly Cited
2006
Endogenous small RNAs (miRNAs) regulate gene expression by mechanisms conserved across metazoans. While the number of verified… (More)
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Highly Cited
2006
Highly Cited
2006
The heterogeneity and instability of human tumors hamper straightforward identification of cancer-causing mutations through… (More)
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Highly Cited
2006
Highly Cited
2006
Recent studies have indicated the existence of tumorigenesis barriers that slow or inhibit the progression of preneoplastic… (More)
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Highly Cited
2005
Highly Cited
2005
To date, more than 200 microRNAs have been described in humans; however, the precise functions of these regulatory, non-coding… (More)
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Highly Cited
1992
Highly Cited
1992
The effect of mammary gland-specific expression of the polyomavirus middle T antigen was examined by establishing lines of… (More)
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Highly Cited
1989
Highly Cited
1989
Carcinoma of the breast and ovary account for one-third of all cancers occurring in women and together are responsible for… (More)
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Highly Cited
1987
Highly Cited
1987
The HER-2/neu oncogene is a member of the erbB-like oncogene family, and is related to, but distinct from, the epidermal growth… (More)
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