• Publications
  • Influence
A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes
It is found that in the fish medaka the Y chromosome-specific region spans only about 280 kb and contains a duplicated copy of the autosomal DMRT1 gene, named D MRT1Y, which is the only functional gene in this chromosome segment and maps precisely to the male sex-determining locus. Expand
Medaka — a model organism from the far east
Medaka, the Far Eastern cousin of Zebrafish, is emerging as an important model fish, because of recent additions to the genetic toolkit available for this organism. Expand
Gene and genome duplications in vertebrates: the one-to-four (-to-eight in fish) rule and the evolution of novel gene functions.
The increased genetic complexity of fish might reflect their evolutionary success and diversity, and many others evolved new functions particularly during development. Expand
Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle
It is found that massive gene loss occurred in the wake of sex-chromosome 'birth' in Cynoglossus semilaevis, and the sex chromosomes of these fish are derived from the same ancestral vertebrate protochromosome as the avian W and Z chromosomes. Expand
Recurrent origin of a sexually selected trait in Xiphophorus fishes inferred from a molecular phylogeny
A molecular phylogeny of Xiphophorus is presented which differs from the traditional one: it indicates that the sword originated and was lost repeatedly, thus questioning the applicability of the pre-existing bias hypothesis as an explanation for the evolution of this sexually selected trait. Expand
The African coelacanth genome provides insights into tetrapod evolution.
Through a phylogenomic analysis, it is concluded that the lungfish, and not the coelacanth, is the closest living relative of tetrapods. Expand
Multiple lineages of the non-LTR retrotransposon Rex1 with varying success in invading fish genomes.
Phylogenetic analysis revealed that Rex1 retrotransposons were frequently active during fish evolution and formed multiple ancient lineages, which underwent several independent and recent bursts of retrotransposition and invaded fish genomes with varying success. Expand
Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus
It is shown that the level of expression of the melanoma oncogene correlates with the degree of malignancy of the tumour, and the corresponding proto-oncogene is developmentally regulated. Expand
First report on chicken genes and chromosomes 2000
Production of medakafish chimeras from a stable embryonic stem cell line.
It is demonstrated that Mes1 cells also have the competence for chimera formation; 90% of host blastulae transplanted with Mes 1 cells developed into chimeric fry. Expand