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Protein Geranylgeranylation

Known as: C-terminal protein geranylgeranylation, Geranylgeranylation, Protein, protein amino acid geranylgeranylation 
OBSOLETE. The covalent or non-covalent attachment of a geranylgeranyl group to the carboxy terminus of a protein. [GOC:jl]
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

GeranylgeranylationProtein Prenylation

Papers overview

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2019
2019
Control of antiviral innate immune response by protein geranylgeranylation
The mitochondrial antiviral signaling protein (MAVS) orchestrates host antiviral innate immune response to RNA virus infection… Expand
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2018
2018
Geranylgeranyl pyrophosphate synthase facilitates the organization of cardiomyocytes during mid-gestation through modulating protein geranylgeranylation in mouse heart
Aims With the maturation of placenta, ventricular chamber maturation enhances cardiac contractile performance to adapt to the… Expand
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2016
2016
GGPPS-mediated Rab27A geranylgeranylation regulates β cell dysfunction during type 2 diabetes development by affecting insulin granule docked pool formation.
Loss of first-phase insulin secretion associated with β cell dysfunction is an independent predictor of type 2 diabetes mellitus… Expand
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2015
2015
Atorvastatin reduces long pentraxin 3 expression in vascular cells by inhibiting protein geranylgeranylation.
BACKGROUND The long pentraxin PTX3 is an acute-phase multi-functional protein that might play both positive and detrimental… Expand
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2007
2007
SnapShot: Rho Family GTPases
Rho RhoA (RHOA) Plasma membrane (PM) and cytosol/­ geranylgeranylation (GG), phosphorylation (PH), ubiquitination (Ub) 
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2006
2006
Erythropoietin receptor signal transduction requires protein geranylgeranylation.
Erythropoietin (Epo) acts through the erythropoietin receptor, a member of the type-1 cytokine receptor family, to influence… Expand
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2003
2003
Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels.
HMG-CoA reductase is the rate-limiting enzyme of the mevalonate pathway leading to the formation of cholesterol and isoprenoids… Expand
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2003
2003
Protein geranylgeranylation is critical for the regulation of survival and proliferation of lymphoma tumor cells.
PURPOSE Prenylation is essential for membrane localization and participation of proteins in various signaling pathways. The… Expand
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Highly Cited
2002
Highly Cited
2002
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
Geranylgeranylation of RhoA small G-protein is essential for its localization to cell membranes and for its biological functions… Expand
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1996
1996
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
We have used specific inhibitors for farnesyltransferase (FTase) and geranylgeranyltransferase (GGTase) I as well as combinations… Expand
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