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Geranylgeranylation

 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Prenylation

Narrower (1)

Protein Geranylgeranylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation
PDZ binding-kinase (PBK) (also named T-lymphokine-activated killer cell-originated protein kinase (TOPK)), a serine/threonine… Expand
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Review
2014
Review
2014
The role of lipid post–translational modification in plant developmental processes
  • M. Running
  • Front. Plant Sci.
  • 2014
    • Corpus ID: 14125329
Most eukaryotic proteins are post-translationally modified, and modification has profound effects on protein function. One key… Expand
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2010
2010
Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency
Mevalonate kinase deficiency (MKD) is an autoinflammatory disorder caused by mutations in the MVK gene resulting in decreased… Expand
2007
2007
Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro
Bisphosphonates are widely used agents for the treatment of malignant bone disease. They inhibit osteoclast-mediated bone… Expand
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2005
2005
Thrombin-induced Rapid Geranylgeranylation of RhoA as an Essential Process for RhoA Activation in Endothelial Cells*
RhoA plays a critical signaling role in thrombin-induced endothelial dysfunction. The possible thrombin regulation of… Expand
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2005
2005
Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo
BackgroundAvailable in vitro and in vivo methods for verifying protein substrates for posttranslational modifications via… Expand
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Highly Cited
2004
Highly Cited
2004
Inhibition of Geranylgeranylation Mediates the Effects of 3-Hydroxy-3-methylglutaryl (HMG)-CoA Reductase Inhibitors on Microglia*
Inflammatory responses involving microglia, the resident macrophages of the brain, are thought to contribute importantly to the… Expand
Highly Cited
2001
Highly Cited
2001
Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase.
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) may exert pleiotropic effects on vascular cells independent… Expand
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1996
1996
Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins.
A novel series of stable analogs of geranylgeranyl diphosphate (GGdP) are described in which the biologically labile diphosphate… Expand
Highly Cited
1990
Highly Cited
1990
Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.
smg p21A and -B are small GTP-binding proteins that share putative effector and consensus C-terminal sequences with ras p21… Expand
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