Geranylgeranylation

PDZ binding-kinase (PBK) (also named T-lymphokine-activated killer cell-originated protein kinase (TOPK)), a serine/threonine… (More)

Recent studies have suggested that statins, the inhibitors for 3-hydroxy-3-methyglutaryl (HMG)-CoA reductase in the mevalonate… (More)

Erythropoietin (Epo) is a cytokine that is required for the survival of erythroid progenitors through interaction with its… (More)

RhoA plays a critical signaling role in thrombin-induced endothelial dysfunction. The possible thrombin regulation of… (More)

OBJECTIVE To investigate effects of zoledronic acid on apoptosis and adhesion to mineralized matrix in prostate cancer cells, to… (More)

Bisphosphonates (BPs) include potent inhibitors of bone resorption used to treat osteoporosis and other bone diseases. BPs… (More)

Recently, we have designed farnesyltransferase and geranylgeranyltransferase I inhibitors (FTI-277 and GGTI-298) that selectively… (More)

Ras proteins are small GTP-binding proteins which are critical for cell signaling and proliferation. Four Ras isoforms exist: Ha… (More)

In order to assess the relative contributions of farnesylated and/or geranylgeranylated proteins on cell cycle progression from… (More)

Geranylgeranylation of Rab GTPases is an essential post-translational modification that enables Rabs to associate with… (More)