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Geranylgeranylation

 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Prenylation

Narrower (1)

Protein Geranylgeranylation

Papers overview

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2015
2015
PBK/TOPK mediates geranylgeranylation signaling for breast cancer cell proliferation
PDZ binding-kinase (PBK) (also named T-lymphokine-activated killer cell-originated protein kinase (TOPK)), a serine/threonine… Expand
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2011
2011
Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines.
Prenylation is a post-translational hydrophobic modification of proteins, important for their membrane localization and… Expand
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2010
2010
Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency
Mevalonate kinase deficiency (MKD) is an autoinflammatory disorder caused by mutations in the MVK gene resulting in decreased… Expand
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2007
2007
Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro.
Bisphosphonates are widely used agents for the treatment of malignant bone disease. They inhibit osteoclast-mediated bone… Expand
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2006
2006
Simvastatin potentiates tumor necrosis factor alpha-mediated apoptosis of human vascular endothelial cells via the inhibition of the geranylgeranylation of RhoA.
HMG-CoA reductase inhibitors (statins) are widely used in the treatment and prevention of atherosclerosis. Here we demonstrate… Expand
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2005
2005
Thrombin-induced rapid geranylgeranylation of RhoA as an essential process for RhoA activation in endothelial cells.
RhoA plays a critical signaling role in thrombin-induced endothelial dysfunction. The possible thrombin regulation of… Expand
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2005
2005
Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo
BackgroundAvailable in vitro and in vivo methods for verifying protein substrates for posttranslational modifications via… Expand
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2004
2004
Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia.
Inflammatory responses involving microglia, the resident macrophages of the brain, are thought to contribute importantly to the… Expand
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Highly Cited
2001
Highly Cited
2001
Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin AT1 receptor expression and Rac1 GTPase.
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) may exert pleiotropic effects on vascular cells independent… Expand
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1990
1990
Posttranslationally processed structure of the human platelet protein smg p21B: evidence for geranylgeranylation and carboxyl methylation of the C-terminal cysteine.
smg p21A and -B are small GTP-binding proteins that share putative effector and consensus C-terminal sequences with ras p21… Expand
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