Geranylgeranylation
National Institutes of Health
Papers overview
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Zoledronate is a standard treatment for preventing skeletal complications of osteoporosis and some types of cancer associated…
Most eukaryotic proteins are post-translationally modified, and modification has profound effects on protein function. One key…
Mevalonate kinase deficiency (MKD) is an autoinflammatory disorder caused by mutations in the MVK gene resulting in decreased…
Bisphosphonates are widely used agents for the treatment of malignant bone disease. They inhibit osteoclast-mediated bone…
BackgroundAvailable in vitro and in vivo methods for verifying protein substrates for posttranslational modifications via…
RhoA plays a critical signaling role in thrombin-induced endothelial dysfunction. The possible thrombin regulation of…
Inflammatory responses involving microglia, the resident macrophages of the brain, are thought to contribute importantly to the…
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) may exert pleiotropic effects on vascular cells independent…
A novel series of stable analogs of geranylgeranyl diphosphate (GGdP) are described in which the biologically labile diphosphate…
smg p21A and -B are small GTP-binding proteins that share putative effector and consensus C-terminal sequences with ras p21…