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Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine…
- M. Blaskovich, Jiazhi Sun, A. Cantor, J. Turkson, R. Jove, S. Sebti
- Biology, ChemistryCancer research
- 15 March 2003
TLDR
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
- K. Siddiquee, Shumin M. Zhang, J. Turkson
- Chemistry, BiologyProceedings of the National Academy of Sciences
- 1 May 2007
TLDR
Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt
- Lin Yang, Han C. Dan, J. Cheng
- Biology, ChemistryCancer Research
- 1 July 2004
TLDR
Discovery of a Novel Shp2 Protein Tyrosine Phosphatase Inhibitor
- Liwei Chen, S. Sung, Jie Wu
- Biology, ChemistryMolecular Pharmacology
- 1 August 2006
TLDR
Targeting protein prenylation for cancer therapy
- N. Berndt, A. Hamilton, S. Sebti
- Biology, ChemistryNature Reviews Cancer
- 1 November 2011
TLDR
Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes (*)
TLDR
The Phosphoinositide 3-OH Kinase/AKT2 Pathway as a Critical Target for Farnesyltransferase Inhibitor-Induced Apoptosis
- K. Jiang, D. Coppola, J. Cheng
- Biology, ChemistryMolecular and Cellular Biology
- 1 January 2000
TLDR
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin,…
- J. Sun, M. Blaskovich, S. Sebti
- Biology, ChemistryCancer research
- 1 October 1999
TLDR
Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
- J. Sun, M. Blaskovich, R. Jove, S. Livingston, D. Coppola, S. Sebti
- Chemistry, MedicineOncogene
- 21 February 2008
TLDR
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human…
- E. Lerner, Tingjun Zhang, D. Knowles, Y. Qian, A. Hamilton, S. Sebti
- BiologyOncogene
- 1997
TLDR
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