Protein Prenylation

Known as: C-terminal protein prenylation, Prenylation, Protein, protein amino acid prenylation 
A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl… (More)
National Institutes of Health

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Broader (1)

Prenylation

Narrower (3)

Protein FarnesylationProtein GeranylgeranylationProtein Isoprenylation
aspects of radiation effectsphysiological aspects

Papers overview

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2017
2017
HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival
Statins are a well-established family of drugs that lower cholesterol levels via the competitive inhibition of the enzyme 3… (More)
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2013
2013
The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway.
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme… (More)
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2013
2013
Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform.
S-prenylation is an important lipid modification that targets proteins to membranes for cell signaling and vesicle trafficking in… (More)
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2012
2012
β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage.
Accumulation of β-amyloid (Aβ) inside brain neurons is an early and crucial event in Alzheimer's disease (AD). Studies in brains… (More)
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2010
2010
Evaluation of alkyne-modified isoprenoids as chemical reporters of protein prenylation.
Protein prenyltransferases catalyze the attachment of C15 (farnesyl) and C20 (geranylgeranyl) groups to proteins at specific… (More)
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2009
2009
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
Simvastatin inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which catalyses conversion of HMG-CoA to… (More)
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2008
2008
High-content assay to study protein prenylation.
The mevalonate pathway leads to synthesis of cholesterol and isoprenoid lipids. Prenyltransferases attach the isoprenoid lipids… (More)
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Review
2006
Review
2006
Therapeutic intervention based on protein prenylation and associated modifications.
In eukaryotic cells, a specific set of proteins are modified by C-terminal attachment of 15-carbon farnesyl groups or 20-carbon… (More)
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Highly Cited
2003
Highly Cited
2003
Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation.
Statins such as simvastatin are 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors that inhibit cholesterol synthesis. We… (More)
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Review
1995
Review
1995
Mechanisms of protein prenylation and role in G protein function.
Introduction Covalent attachment of isoprenoid lipids is now recognized as an important modification of many proteins involved in… (More)
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