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Protein Prenylation

Known as: C-terminal protein prenylation, Prenylation, Protein, protein amino acid prenylation 
A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl… 
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Abstract The mevalonate–isoprenoid–cholesterol biosynthesis pathway plays a key role in human health and disease. The importance… 
2015
2015
G protein‐regulated cell function is crucial for cardiomyocytes, and any deregulation of its gene expression or protein… 
Highly Cited
2013
Highly Cited
2013
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme… 
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Highly Cited
2013
Highly Cited
2013
S-prenylation is an important lipid modification that targets proteins to membranes for cell signaling and vesicle trafficking in… 
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Highly Cited
2010
Highly Cited
2010
Protein prenyltransferases catalyze the attachment of C15 (farnesyl) and C20 (geranylgeranyl) groups to proteins at specific… 
2009
2009
Simvastatin inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which catalyses conversion of HMG-CoA to… 
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Review
2006
Review
2006
In eukaryotic cells, a specific set of proteins are modified by C-terminal attachment of 15-carbon farnesyl groups or 20-carbon… 
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Highly Cited
2003
Highly Cited
2003
Statins such as simvastatin are 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors that inhibit cholesterol synthesis. We… 
2002
2002
Apolipoprotein E (ApoE) genotype modulates the risk of Alzheimer's disease. ApoE has been shown essential for amyloid beta… 
Highly Cited
2000
Highly Cited
2000
Phenylacetate (PA) and phenylbutyrate (PB) are aromatic fatty acids that are presently undergoing evaluation as potential… 
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