Protein Prenylation

Known as: C-terminal protein prenylation, Prenylation, Protein, protein amino acid prenylation 
A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl… (More)
National Institutes of Health

Papers overview

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2017
2017
Statins are a well-established family of drugs that lower cholesterol levels via the competitive inhibition of the enzyme 3… (More)
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2013
2013
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme… (More)
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2013
2013
S-prenylation is an important lipid modification that targets proteins to membranes for cell signaling and vesicle trafficking in… (More)
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2012
2012
Accumulation of β-amyloid (Aβ) inside brain neurons is an early and crucial event in Alzheimer's disease (AD). Studies in brains… (More)
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2010
2010
Protein prenyltransferases catalyze the attachment of C15 (farnesyl) and C20 (geranylgeranyl) groups to proteins at specific… (More)
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2009
2009
Simvastatin inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which catalyses conversion of HMG-CoA to… (More)
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2008
2008
The mevalonate pathway leads to synthesis of cholesterol and isoprenoid lipids. Prenyltransferases attach the isoprenoid lipids… (More)
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Review
2006
Review
2006
In eukaryotic cells, a specific set of proteins are modified by C-terminal attachment of 15-carbon farnesyl groups or 20-carbon… (More)
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Highly Cited
2003
Highly Cited
2003
Statins such as simvastatin are 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors that inhibit cholesterol synthesis. We… (More)
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Review
1995
Review
1995
Introduction Covalent attachment of isoprenoid lipids is now recognized as an important modification of many proteins involved in… (More)
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