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Protein Prenylation

Known as: C-terminal protein prenylation, Prenylation, Protein, protein amino acid prenylation 
A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl… Expand
National Institutes of Health

Related topics

Related topics

6 relations

Broader (1)

Prenylation

Narrower (3)

Protein FarnesylationProtein GeranylgeranylationProtein Isoprenylation
aspects of radiation effectsphysiological aspects

Papers overview

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2015
2015
The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb–mTORC1 signalling and leads to chronic heart failure
G protein‐regulated cell function is crucial for cardiomyocytes, and any deregulation of its gene expression or protein… Expand
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Highly Cited
2013
Highly Cited
2013
The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme… Expand
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2012
2012
β-Amyloid Inhibits Protein Prenylation and Induces Cholesterol Sequestration by Impairing SREBP-2 Cleavage
Accumulation of β-amyloid (Aβ) inside brain neurons is an early and crucial event in Alzheimer's disease (AD). Studies in brains… Expand
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Highly Cited
2010
Highly Cited
2010
Evaluation of Alkyne‐Modified Isoprenoids as Chemical Reporters of Protein Prenylation
Protein prenyltransferases catalyze the attachment of C15 (farnesyl) and C20 (geranylgeranyl) groups to proteins at specific… Expand
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2009
2009
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
Simvastatin inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which catalyses conversion of HMG-CoA to… Expand
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Review
2006
Review
2006
Therapeutic intervention based on protein prenylation and associated modifications
In eukaryotic cells, a specific set of proteins are modified by C-terminal attachment of 15-carbon farnesyl groups or 20-carbon… Expand
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Highly Cited
2003
Highly Cited
2003
Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation.
Statins such as simvastatin are 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors that inhibit cholesterol synthesis. We… Expand
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2002
2002
Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins
Apolipoprotein E (ApoE) genotype modulates the risk of Alzheimer's disease. ApoE has been shown essential for amyloid beta… Expand
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2000
2000
Induction of apoptosis in malignant B cells by phenylbutyrate or phenylacetate in combination with chemotherapeutic agents.
Phenylacetate (PA) and phenylbutyrate (PB) are aromatic fatty acids that are presently undergoing evaluation as potential… Expand
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Review
1995
Review
1995
Mechanisms of protein prenylation and role in G protein function.
  • P. Casey
  • Biochemical Society transactions
  • 1995
    • Corpus ID: 29102829
Introduction Covalent attachment of isoprenoid lipids is now recognized as an important modification of many proteins involved in… Expand
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