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Protein Prenylation
Known as:
C-terminal protein prenylation
, Prenylation, Protein
, protein amino acid prenylation
A post-translational modification of proteins by the attachment of an isoprenoid to the C-terminal cysteine residue. The isoprenoids used, farnesyl…
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National Institutes of Health
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Related topics
Related topics
6 relations
Broader (1)
Prenylation
Narrower (3)
Protein Farnesylation
Protein Geranylgeranylation
Protein Isoprenylation
aspects of radiation effects
physiological aspects
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease
A. Jeong
,
K. Suazo
,
W. Wood
,
M. Distefano
,
Ling Li
Critical reviews in biochemistry and molecular…
2018
Corpus ID: 22604894
Abstract The mevalonate–isoprenoid–cholesterol biosynthesis pathway plays a key role in human health and disease. The importance…
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Review
2017
Review
2017
The mevalonate pathway in neurons: It's not just about cholesterol.
Miguel Moutinho
,
M. J. Nunes
,
E. Rodrigues
Experimental Cell Research
2017
Corpus ID: 21616761
2015
2015
The alteration of protein prenylation induces cardiomyocyte hypertrophy through Rheb–mTORC1 signalling and leads to chronic heart failure
Na Xu
,
Shan Guan
,
+9 authors
Chaojun Li
Journal of Pathology
2015
Corpus ID: 20106444
G protein‐regulated cell function is crucial for cardiomyocytes, and any deregulation of its gene expression or protein…
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Highly Cited
2013
Highly Cited
2013
The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway
Manish Rauthan
,
P. Ranji
,
Nataly Aguilera Pradenas
,
Christophe Pitot
,
M. Pilon
Proceedings of the National Academy of Sciences
2013
Corpus ID: 29876187
Statins are cholesterol-lowering drugs that inhibit 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase, the rate-limiting enzyme…
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2012
2012
β-Amyloid Inhibits Protein Prenylation and Induces Cholesterol Sequestration by Impairing SREBP-2 Cleavage
Amany S. Mohamed
,
Lucila Saavedra
,
A. di Pardo
,
S. Sipione
,
E. Posse de Chaves
Journal of Neuroscience
2012
Corpus ID: 6734020
Accumulation of β-amyloid (Aβ) inside brain neurons is an early and crucial event in Alzheimer's disease (AD). Studies in brains…
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Highly Cited
2010
Highly Cited
2010
Evaluation of Alkyne‐Modified Isoprenoids as Chemical Reporters of Protein Prenylation
A. Degraw
,
C. Palsuledesai
,
+4 authors
M. Distefano
Chemical Biology and Drug Design
2010
Corpus ID: 20275640
Protein prenyltransferases catalyze the attachment of C15 (farnesyl) and C20 (geranylgeranyl) groups to proteins at specific…
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2009
2009
Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation.
T. Maeda
,
N. Horiuchi
Journal of Biochemistry (Tokyo)
2009
Corpus ID: 32254959
Simvastatin inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which catalyses conversion of HMG-CoA to…
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Review
2006
Review
2006
Therapeutic intervention based on protein prenylation and associated modifications
M. Gelb
,
L. Brunsveld
,
+4 authors
H. Waldmann
Nature Chemical Biology
2006
Corpus ID: 42964172
In eukaryotic cells, a specific set of proteins are modified by C-terminal attachment of 15-carbon farnesyl groups or 20-carbon…
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Highly Cited
2003
Highly Cited
2003
Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation.
T. Maeda
,
T. Kawane
,
N. Horiuchi
Endocrinology
2003
Corpus ID: 21130271
Statins such as simvastatin are 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors that inhibit cholesterol synthesis. We…
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Highly Cited
2000
Highly Cited
2000
Induction of apoptosis in malignant B cells by phenylbutyrate or phenylacetate in combination with chemotherapeutic agents.
T. Witzig
,
M. Timm
,
M. Stenson
,
P. Svingen
,
S. Kaufmann
Clinical Cancer Research
2000
Corpus ID: 2362976
Phenylacetate (PA) and phenylbutyrate (PB) are aromatic fatty acids that are presently undergoing evaluation as potential…
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