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Lucibufagins: Defensive steroids from the fireflies Photinus ignitus and P. marginellus (Coleoptera: Lampyridae).
- T. Eisner, D. Wiemer, L. W. Haynes, J. Meinwald
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 February 1978
Feeding tests with thrushes (Hylocichla spp.) led to the isolation of three novel steroid pyrones from fireflies (Photinus ignitus and P. marginellus) responsible, in part at least, for the… Expand
Naphthoquinones in defensive secretion of an opilionid
The defensive secretion of the opilionidPhalangium opilio contains 1,4-naphthoquinone and 6-methyl-1,4-naphthoquinone. Naphthoquinones are of rate occurrence in arthropods, having previously been… Expand
Pseudohypericin is necessary for the light-activated inhibition of prostaglandin E2 pathways by a 4 component system mimicking an Hypericum perforatum fraction.
Hypericum perforatum (Hp) has been used medicinally to treat a variety of conditions including mild-to-moderate depression. Recently, several anti-inflammatory activities of Hp have been reported. An… Expand
Synthesis and biological activity of isoprenoid bisphosphonates.
- Larry W. Shull, A. Wiemer, R. Hohl, D. Wiemer
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 15 June 2006
Bisphosphonates have been used in the clinic to treat osteoporosis and to reduce bone resorption and the accompanying pathological bone fractures that attend a number of malignancies including… Expand
Geranylgeranyl Diphosphate Synthase: An Emerging Therapeutic Target
Proteins modified post‐translationally by geranylgeranylation have been implicated in numerous cellular processes related to human disease. In recent years, the study of protein geranylgeranylation… Expand
Isoprenoid metabolism as a therapeutic target in gram-negative pathogens.
- A. Wiemer, C. C. Hsiao, D. Wiemer
- Biology, Medicine
- Current topics in medicinal chemistry
- 30 November 2010
Gram-negative Enterobacteria include a variety of human pathogens, perhaps most notably E. coli, Salmonella, Shigella, Yersinia, and Proteus. While there are treatment options for the diseases caused… Expand
Ant-repellent triterpenoids from Cordia alliodora
An antifungal terpenoid defends a neotropical tree (Hymenaea) against attack by fungus-growing ants (Atta)
SummaryForagers of the leafcutting ant, Atta cephalotes L. (Formicidae, Attini) seldom or never attack many of the plant species available to them in nature. In the semideciduous forests of lowland… Expand
Flavanones from Lonchocarpus minimiflorus
Abstract Five novel flavanones have been isolated from the leaves of the Costa Rican tree Lonchocarpus minimiflorus , and characterized on the basis of their spectral features. Three of these… Expand
Piplaroxide, an ant-repellent piperidine epoxide from Piper tuberculatum
Investigation of leaves from the shrub Piper tuberculatum for compounds that might serve as repellents to leafcutting ants has led to identification of three cinnamic acid derivatives. One has been… Expand