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Magnolol Protects against MPTP/MPP+-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson's Disease
TLDR
Magnolol has protective effects via an antioxidative mechanism in both in vivo and in vitro models of Parkinson's disease and in human neuroblastoma SH-SY5Y cells, magnolol significantly attenuated MPP+-induced cytotoxicity and the production of reactive oxygen species. Expand
Global-scale projection and its sensitivity analysis of the health burden attributable to childhood undernutrition under the latest scenario framework for climate change research
This study assessed the health burden attributable to childhood underweight through 2050 focusing on disability-adjusted life years (DALYs), by considering the latest scenarios for climate changeExpand
Amoebic encephalitis in a farmer.
TLDR
A dual point-of-care test shows good performance in simultaneously detecting nontreponemal and trep onemal antibodies in patients with syphilis: a multisite evaluation study in China. Expand
Multiple activation mechanisms of serotonin-mediated contraction in the carotid arteries obtained from spontaneously hypertensive rats
TLDR
5-HT-mediated contraction was increased in the carotid arteries obtained from spontaneously hypertensive rats and multiple signaling pathways such as ERK1/2, p38 MAPK, JNK, PI3K, ROCK, and PDK1 were utilized. Expand
Loss of striatal dopaminergic terminals during the early stage in response to MPTP injection in C57BL/6 mice
TLDR
The isolated DAergic synaptosomes can be useful to identify mechanisms of loss of the nerve terminals and GBR-12909, a dopamine uptake inhibitor, completely reversed the MPTP-induced decrease of DAT protein in the DAergicsynaptosome. Expand
Tunicamycin-Induced Alterations in the Vasorelaxant Response in Organ-Cultured Superior Mesenteric Arteries of Rats.
TLDR
Short-term treatment with tunicamycin not only caused endothelial dysfunction but also impaired cAMP- and KATP-mediated responses in the superior mesenteric arteries of rats, providing new insight into ER stress in vascular dysfunction. Expand
UDP-induced relaxation is enhanced in aorta from female obese Otsuka Long–Evans Tokushima Fatty rats
TLDR
Findings demonstrate opposite trends of relaxations by UDP and ACh in OLETF and LETO rat aortas, which may be attributed to the imbalance between NO and vasoconstrictor prostanoids upon stimulations. Expand
N-Methyl-4-phenylpyridinium and an endogenously formed analog, N-methylated β-carbolinium, inhibit striatal tyrosine hydroxylation in freely moving rats
TLDR
The present study revealed that MPP+ and 2,9-Me2NH+ were taken up into dopaminergic neurons and then inhibited in vivo dopamine synthesis prior to cell death possibly in different manners. Expand
In vitro selection of random peptides against artificial lipid bilayers: a potential tool to immobilize molecules on membranes.
The first in vitro selection of binding peptides against artificial lipid membranes from a random peptide library using an in vitro display method (cDNA display) is reported. The selected peptide,Expand
Lithium ion phase-transfer reaction at the interface between the lithium manganese oxide electrode and the nonaqueous electrolyte.
TLDR
The dependency on the solvent suggests that both steps in the lithium ion phase-transfer at the electrode/electrolyte interface include the desolvation process and have high activation barriers. Expand
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