K. Abe

Publications905
h-index70
Citations23,682
Highly Influential Citations920
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • T. Yamashita
  • 339 Publications • 5,489 Citations
  • Y. Ohta
  • 277 Publications • 3,551 Citations
  • N. Hishikawa
  • 236 Publications • 3,067 Citations
  • K. Deguchi
  • 194 Publications • 3,380 Citations
  • Publications
  • Influence
The possible role of hydrogen sulfide as an endogenous neuromodulator
  • K. Abe, H. Kimura
  • Biology
    The Journal of neuroscience : the official…
  • 1 February 1996
TLDR
It is shown that physiological concentrations of H2S selectively enhance NMDA receptor-mediated responses and facilitate the induction of hippocampal long-term potentiation, suggesting that endogenous H 2S functions as a neuromodulator in the brain.
View on Publisher
Mutations of optineurin in amyotrophic lateral sclerosis
TLDR
It is shown that there are mutations in the gene encoding optineurin (OPTN), earlier reported to be a causative gene of primary open-angle glaucoma (POAG), in patients with ALS and these findings strongly suggest that OPTN is involved in the pathogenesis of ALS.
View on Nature
Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum
TLDR
Evidence is reported that, after a stroke, subventricular zone GFAP-expressing cells are capable of producing new neurons outside the olfactory bulbs, and long-term tracing of the green fluorescent-labeled cells revealed that the SVZ-derived neuroblasts differentiated into mature neurons in the striatum, in which they expressed neuronal-specific nuclear protein and formed synapses with neighboring striatal cells.
View on Publisher
Expansion of intronic GGCCTG hexanucleotide repeat in NOP56 causes SCA36, a type of spinocerebellar ataxia accompanied by motor neuron involvement.
View on PubMed
Confirmatory double-blind, parallel-group, placebo-controlled study of efficacy and safety of edaravone (MCI-186) in amyotrophic lateral sclerosis patients
TLDR
The reduction of ALSFRS-R was smaller in the edaravone group than in the placebo group, but efficacy of edarvone for treatment of ALS was not demonstrated.
View on Taylor & Francis
Prospective 10-year surveillance of human prion diseases in Japan.
TLDR
A frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease, and unique phenotypes of sporadic Creutzfelder disease and genetic prion diseases related to the characteristic distribution of prion protein gene mutations and polymorphisms in Japan, compared with those in western countries are revealed.
View on PubMed
Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats.
TLDR
The early but dissociative induction of VEGF between neuronal and pial cells suggests different roles of the protein in their cells after transient MCA occlusion.
View on PubMed
Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy
TLDR
It is shown that abnormal expansions of TTTCA and TTTTA repeats in intron 4 of SAMD12 cause benign adult familial myoclonic epilepsy (BAFME), and RNA toxicity as the mechanism underlying disease pathogenesis is identified.
View on Springer
Longitudinal study of cerebrospinal fluid levels of tau, Aβ1–40, and Aβ1–42(43) in Alzheimer's disease: A study in Japan
TLDR
It is suggested that CSF tau may increase with the clinical progression of dementia and that the alteration of the CSF level of Aβ1–42(43) and the ratio of A β1–40 to Aβ 1–42 (43) may start at early stages in AD.
View on Wiley
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease
TLDR
Administration of melatonin partially inhibited the expected time‐dependent elevation of β‐amyloid, reduced abnormal nitration of proteins, and increased survival in the treated transgenic mice, and these findings may bear relevance to the pathogenesis and therapy of AD.
View on Wiley
...
...