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Prostacyclin synthase

Known as: PGI2 synthetase, CYP8A1, PGI isomerase 
Prostacyclin synthase (500 aa, ~57 kDa) is encoded by the human PTGIS gene. This protein plays a role in the mediation of prostaglandin biosynthesis.
National Institutes of Health

Related topics

Related topics

14 relations
Arachidonic Acid Metabolism PathwayCytochrome P450Endoplasmic ReticulumEnzyme Gene

Broader (1)

Intramolecular Oxidoreductases

Papers overview

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Highly Cited
1994
Highly Cited
1994
Molecular cloning and expression of human prostacyclin synthase.
The cDNA for human prostacyclin synthase was cloned by polymerase chain reaction using poly(A)+ RNA from human aortic endothelial… 
Highly Cited
1985
Highly Cited
1985
Formation of 15-HETE as a major hydroxyeicosatetraenoic acid in the atherosclerotic vessel wall.
1985
1985
Metabolism of [1-14C]-arachidonic acid by cultured calf aortic endothelial cells: evidence for the presence of a lipoxygenase pathway.
Review
1985
Review
1985
The biochemical pharmacology of thromboxane synthase inhibition in man.
Selective inhibitors of thromboxane synthase have two theoretical advantages over inhibitors of the cyclooxygenase enzyme as… 
Highly Cited
1980
Highly Cited
1980
Low density lipoproteins (LDL) are carriers for lipid peroxides and inhibit prostacyclin (PGI2) biosynthesis in arteries.
Serum lipid peroxides are concentrated in the LDL fraction. HDL and plasma proteins quench the interaction of LDL lipid peroxides… 
Highly Cited
1979
Highly Cited
1979
Peroxidase-dependent deactivation of prostacyclin synthetase.
A study of the enzymes of the arachidonic acid cascade revealed a high sensitivity of prostacyclin synthetase and a complete… 
Highly Cited
1978
Highly Cited
1978
Transformation of arachidonic acid and prostaglandin endoperoxides by the guinea pig heart. Formation of RCS and prostacyclin.
Highly Cited
1978
Highly Cited
1978
Synthesis of prostaglandin 6-keto F1alpha by cultured aortic smooth muscle cells and stimulation of its formation in a coupled system with platelet lysates.
Highly Cited
1977
Highly Cited
1977
Prostacyclin increases cyclic AMP levels and adenylate cyclase activity in platelets
PROSTACYCLIN (PGX) (ref. 1) is the name proposed for the metabolic product of a recently discovered enzymic transformation of the… 
Highly Cited
1977
Highly Cited
1977
Inhibition of platelet aggregation by a placental substance with prostacyclin-like activity
THE demonstration that certain arteries and veins have the ability to generate from prostaglandin (PG) endoperoxides an unstable… 
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