Prostacyclin synthase

Known as: PGI2 synthetase, CYP8A1, PGI isomerase 
Prostacyclin synthase (500 aa, ~57 kDa) is encoded by the human PTGIS gene. This protein plays a role in the mediation of prostaglandin biosynthesis.
National Institutes of Health

Papers overview

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Review
2007
Review
2007
When working on the regulation of prostacyclin synthase (PGIS), we found that PGIS was selectively inhibited by peroxynitrite… (More)
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Highly Cited
2006
Highly Cited
2006
Insulin resistance markedly increases cardiovascular disease risk in people with normal glucose tolerance, even after adjustment… (More)
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Review
2005
Review
2005
Prostacyclin synthase (PGIS) cDNA comprises 1500 nucleotides coding for a 500 amino acid protein. It is a heme protein with… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND In addition to being a risk marker for cardiovascular disease, much recent data suggest that C-reactive protein (CRP… (More)
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Highly Cited
2003
Highly Cited
2003
To better define the role of the various prostanoid synthases in the adjuvant-induced arthritis (AIA) model, we have determined… (More)
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Highly Cited
2002
Highly Cited
2002
Loss of the modulatory role of the endothelium may be a critical initial factor in the development of diabetic vascular diseases… (More)
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Highly Cited
2002
Highly Cited
2002
Peroxynitrite, a marker of oxidative stress, is elevated in conditions associated with vascular endothelial cell dysfunction… (More)
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Highly Cited
2002
Highly Cited
2002
Inhibition of cyclooxygenase (COX) activity decreases eicosanoid production and prevents lung cancer in animal models… (More)
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Highly Cited
1999
Highly Cited
1999
Prostacyclin is a powerful vasodilator and inhibits platelet adhesion and cell growth. We hypothesized that a decrease in… (More)
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Highly Cited
1999
Highly Cited
1999
Prostacyclin synthase (PGIS) is the final committed enzyme in the metabolic pathway leading to prostacyclin (PGI2) production… (More)
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