Skip to search formSkip to main contentSkip to account menu

Proprotein Convertase 9

Known as: Convertase 9, Proprotein, Proprotein Convertase, Subtilisin Kexin Type 9, Proprotein Convertase 9 [Chemical/Ingredient] 
A proprotein convertase that is essential for CHOLESTEROL homeostasis. It binds to and is required for the lysosomal degradation of the LDL RECEPTOR… 
National Institutes of Health

Related topics

Related topics

9 relations
In BloodPCSK9 geneProcess of secretionantagonists & inhibitors

Narrower (1)

PCSK9 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
On the function and homeostasis of PCSK9: reciprocal interaction with LDLR and additional lipid effects.
Highly Cited
2014
Highly Cited
2014
Compositional studies and biological activities of some mash bean (Vigna mungo (L.) Hepper) cultivars commonly consumed in Pakistan
BackgroundIn recent years, the desire to adopt a healthy diet has drawn attention to legume seeds and food products derived from… 
Highly Cited
2012
Highly Cited
2012
Peroxisome Proliferator-activated Receptor γ Activation by Ligands and Dephosphorylation Induces Proprotein Convertase Subtilisin Kexin Type 9 and Low Density Lipoprotein Receptor Expression*
Background: PCSK9 regulates cholesterol homeostasis by enhancing the LDLR protein degradation. The effects of PPARγ on PCSK9 and… 
Review
2011
Review
2011
Clinical aspects of PCSK9.
Review
2009
Review
2009
Molecular basis of PCSK9 function.
Highly Cited
2009
Highly Cited
2009
Inhibition of PCSK9: A powerful weapon for achieving ideal LDL cholesterol levels
Plasma LDL cholesterol level is a major determinant of cardiovascular disease (CVD) risk. The striking results of the early large… 
Highly Cited
2009
Highly Cited
2009
Degradation of LDLR protein mediated by 'gain of function' PCSK9 mutants in normal and ARH cells.
Review
2008
Review
2008
PCSK9 and LDL cholesterol: unravelling the target to design the bullet.
Highly Cited
2008
Highly Cited
2008
Identification and characterization of two non-secreted PCSK9 mutants associated with familial hypercholesterolemia in cohorts from New Zealand and South Africa.
Highly Cited
2006
Highly Cited
2006
Fasting induces hyperlipidemia in mice overexpressing proprotein convertase subtilisin kexin type 9: lack of modulation of very-low-density lipoprotein hepatic output by the low-density lipoprotein…
Several proprotein convertase subtilisin kexin type 9 (PCSK9) mutations lead to familial hypercholesterolemia by virtue of its… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)