• Publications
  • Influence
HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells.
High-density lipoproteins (HDL) have many biological functions, including reducing endothelial activation and adhesion molecule expression. We recently reported that HDL transport and deliverExpand
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The PCSK9 decade
PCSK9 proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor. In recentExpand
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Cardiac sympathetic nerve function in congestive heart failure.
BACKGROUND Increased availability of norepinephrine (NE) for activation of cardiac adrenoceptors (increased cardiac adrenergic drive) and depletion of myocardial NE stores may contribute to theExpand
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Nonenzymatic Glycation Impairs the Antiinflammatory Properties of Apolipoprotein A-I
Objective—The goal of this study was to investigate the effects of nonenzymatic glycation on the antiinflammatory properties of apolipoprotein (apo) A-I. Methods and Results—Rabbits were infused withExpand
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Increased sympathetic nerve activity in renovascular hypertension.
BACKGROUND Increased sympathetic nerve activity may contribute to the progression of renovascular hypertension. Because previous results have been inconclusive, we investigated whether renovascularExpand
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Hepatocyte nuclear factor 4&agr; in the intestinal epithelial cells protects against inflammatory bowel disease
Background: Hepatocyte nuclear factor 4&agr; (HNF4&agr;; NR2A1) is an orphan member of the nuclear receptor superfamily expressed in liver and intestine. While HNF4&agr; expression is critical forExpand
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Unravelling the functional significance of PCSK9
  • G. Lambert
  • Biology, Medicine
  • Current opinion in lipidology
  • 1 June 2007
Purpose of review Proprotein convertase subtilisin kexin type 9 (PCSK9) has emerged as a potential target for lowering plasma LDL cholesterol levels. This review summarizes recent studies publishedExpand
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PCSK9 and lipoprotein (a) levels are two predictors of coronary artery calcification in asymptomatic patients with familial hypercholesterolemia.
BACKGROUND AND AIMS We aimed to assess whether elevated PCSK9 and lipoprotein (a) [Lp(a)] levels associate with coronary artery calcification (CAC), a good marker of atherosclerosis burden, inExpand
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Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment.
BACKGROUND Proprotein convertase subtilisin/kexin type 9 (PCSK9) promotes the degradation of the LDL receptor (LDLr) in hepatocytes, and its expression in mouse liver has been shown to decrease withExpand
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Molecular basis of PCSK9 function.
The LDL receptor (LDLr) inhibitor Proprotein Convertase Subtilisin Kexin type 9 (PCSK9) has emerged as a genetically validated target for lowering plasma LDL cholesterol levels. In 2007, PCSK9 wasExpand
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