On the function and homeostasis of PCSK9: reciprocal interaction with LDLR and additional lipid effects.

@article{Tavori2015OnTF,
  title={On the function and homeostasis of PCSK9: reciprocal interaction with LDLR and additional lipid effects.},
  author={Hagai Tavori and Shirya Rashid and Sergio Fazio},
  journal={Atherosclerosis},
  year={2015},
  volume={238 2},
  pages={264-70}
}
Proprotein convertase subtilisin kexin type 9 (PCSK9) is a circulatory ligand that terminates the lifecycle of the low-density lipoprotein (LDL) receptor (LDLR) thus affecting plasma LDL-cholesterol (LDL-C) levels. Recent evidence shows that in addition to the straightforward mechanism of action, there are more complex interactions between PCSK9, LDLR and plasma lipoprotein levels, including: (a) the presence of both parallel and reciprocal regulation of surface LDLR and plasma PCSK9; (b) a… CONTINUE READING
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Clearance of Plasma Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) by LDL Apheresis

PB D.G. Duell, NG Seidah, J. Davignon
Circ Res • 2014

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