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PCSK9 gene

Known as: NARC-1, NEURAL APOPTOSIS-REGULATED CONVERTASE 1, Proprotein Convertase Subtilisin/Kexin Type 9 Gene 
This gene is involved in both cholesterol metabolism and protein degradation.
National Institutes of Health

Related topics

Related topics

7 relations
Cholesterol HomeostasisHYPERCHOLESTEROLEMIA, AUTOSOMAL DOMINANT, 3HydrolysisPCSK9 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Circulating Rather Than Intestinal PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Regulates Postprandial Lipemia in Mice
Supplemental Digital Content is available in the text. Objective: Increased postprandial lipemia (PPL) is an independent risk… 
2015
2015
Diabetes with poor glycaemic control does not promote atherosclerosis in genetically modified hypercholesterolaemic minipigs
Aims/hypothesisDiabetes is associated with an increased risk of atherosclerotic cardiovascular disease, but whether there is a… 
Review
2015
Review
2015
PCSK9 and triglyceride-rich lipoprotein metabolism
Abstract Pro-protein convertase subtilisin-kexin 9 (PCSK9) is known to affect low-density lipoprotein (LDL) metabolism, but there… 
2014
2014
Influence of PCSK9 polymorphisms on plasma lipids and response to atorvastatin treatment in Brazilian subjects.
2013
2013
Mutation in the PCSK9 Gene in Omani Arab Subjects with Autosomal Dominant Hypercholesterolemia and its Effect on PCSK9 Protein Structure.
Proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL cholesterol (LDL-C) metabolism by virtue of its… 
2012
2012
Genetic variation in APOB, PCSK9, and ANGPTL3 in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL‐Cl Levels
Autosomal Dominant Hypercholesterolemia (ADH) is caused by LDLR and APOB mutations. However, genetically diagnosed ADH patients… 
2008
2008
A PCSK9 variant and familial combined hyperlipidaemia
Background: Our discovery in 2003 of the first mutations of PCSK9 gene causing autosomal dominant hypercholesterolaemia (ADH… 
Review
2008
Review
2008
Further LDL cholesterol lowering through targeting PCSK9 for coronary artery disease.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a serine protease that belongs to the proprotein convertase family… 
Highly Cited
2004
Highly Cited
2004
Genetic variants in PCSK9 affect the cholesterol level in Japanese
AbstractMutations in the proprotein convertase subtilisin/kexin 9 (PCSK9) gene have been reported in affected members of two… 
1989
1989
FH3, a v-myc avian retrovirus with limited transforming ability
We have isolated a new acute avian transforming virus which contains the oncogene myc. This virus, designated FH3, was isolated… 
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