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The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins.
TLDR
These data demonstrate for the first time that ApoA5 is a secreted protein present in human serum and is associated with specific lipoprotein particles, and indicate that the circulating concentration of human Apo A5 is very low compared with other apolipoproteins. Expand
Alloxan is an inhibitor of the enzyme O-linked N-acetylglucosamine transferase.
TLDR
It is demonstrated that alloxan is an inhibitor of OGT, and as such, is the first OGT inhibitor described. Expand
Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9 Published, JLR Papers in Press, November 21, 2007.
TLDR
The results suggest that the addition of a PCSK9 inhibitor to statin therapy may result in even further LDL-C decreases, which are currently seen in patients treated with atorvastatin. Expand
Circulating Proprotein Convertase Subtilisin Kexin Type 9 Has a Diurnal Rhythm Synchronous With Cholesterol Synthesis and Is Reduced by Fasting in Humans
TLDR
Throughout the day, and in response to fasting and cholesterol depletion, circulating PCSK9 displays marked variation, presumably related to oscillations in hepatic cholesterol that modify its activity in parallel with cholesterol synthesis. Expand
Identification and Characterization of a Major Liver Lysophosphatidylcholine Acyltransferase*
TLDR
The studies identify a long-sought enzyme that plays a critical role in PC remodeling in metabolic tissues and provide an invaluable tool for future investigations on howPC remodeling may potentially impact glucose and lipid homeostasis. Expand
AGPAT6 Is a Novel Microsomal Glycerol-3-phosphate Acyltransferase*
TLDR
It is shown that AGPAT6 is a microsomal glycerol-3-phosphate acyltransferase (GPAT), and a renaming of this enzyme GPAT4 is proposed. Expand
High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol
TLDR
While PCSK9 levels were highly correlated with total cholesterol, LDL-C, and triglyceride levels at baseline, atorvastatin completely abolished all of these correlations, suggesting an explanation for why increasing doses of statins fail to achieve proportional LDL- C lowering. Expand
Diacylglycerol hydrolysis to arachidonic acid is necessary for insulin secretion from isolated pancreatic islets: sequential actions of diacylglycerol and monoacylglycerol lipases.
TLDR
It is shown that diacylglycerol, a product of phospholipase C action, is a major source of free arachidonic acid in islets and is markedly inhibits glucose- and carbachol-induced increases in islet arachIDonic acid levels, as measured by gas chromatography with electron-capture detection of its pentafluorobenzyl esters. Expand
Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population.
TLDR
The study indicates that the serum PCSK9 level may be a biomarker of metabolic status and cardiovascular disease and correlated with multiple metabolic variables including age, BMI, total cholesterol, LDL cholesterol, triglycerides, fasting blood glucose, systolic blood pressure (SP) and diastolicBlood pressure (DP) in this population. Expand
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis Published, JLR Papers in Press, April 20, 2007.
TLDR
Results reveal that secreted PCSK9 retains biological activity, is able to bind directly to the LDLR extracellular domain, and undergoes LDLR-ARH-mediated endocytosis, leading to accelerated intracellular degradation of the HDLR. Expand
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