Procainamide

Known as: p-Amino-N-(2-diethylaminoethyl)benzamide, Amide, Procaine, Procainamida 
A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.
National Institutes of Health

Related topics

Related topics

39 relations

Broader (4)

4-Aminobenzoic AcidAnti-Arrhythmia AgentsVoltage-Gated Sodium Channel Blockersphenylamide
Atrial FibrillationAtrial FlutterCisaprideDrug Allergy
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Narrower (15)

N-chloroprocainamideN-propionylprocainamideNovocainamideNovocamid
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Papers overview

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Highly Cited
2005
Highly Cited
2005
Procainamide is a specific inhibitor of DNA methyltransferase 1.
CpG island hypermethylation occurs in most cases of cancer, typically resulting in the transcriptional silencing of critical… (More)
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Highly Cited
2004
Highly Cited
2004
Active transport of imatinib into and out of cells: implications for drug resistance.
Imatinib is a tyrosine kinase inhibitor that is effective in the treatment of chronic myeloid leukemia (CML). Not all patients… (More)
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Highly Cited
2003
Highly Cited
2003
Reactivation of tumor suppressor genes by the cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy.
PURPOSE The purpose of this study is to evaluate the demethylating and tumor suppressor-reactivating activity of hydralazine and… (More)
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Highly Cited
2000
Highly Cited
2000
Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts.
BACKGROUND A mutation in the cardiac sodium channel gene (SCN5A) has been described in patients with the syndrome of right bundle… (More)
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Highly Cited
1999
Highly Cited
1999
Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: electrophysiological characteristics, pharmacological responses, and effects of radiofrequency ablation.
BACKGROUND Atrial fibrillation (AF) can be initiated by ectopic beats originating from the atrial or great venous tissues. This… (More)
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Highly Cited
1997
Highly Cited
1997
Effect of verapamil and procainamide on atrial fibrillation-induced electrical remodeling in humans.
BACKGROUND Atrial fibrillation (AF) shortens the atrial effective refractory period (ERP) and predisposes to further episodes of… (More)
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Highly Cited
1993
Highly Cited
1993
Treating activated CD4+ T cells with either of two distinct DNA methyltransferase inhibitors, 5-azacytidine or procainamide, is sufficient to cause a lupus-like disease in syngeneic mice.
Human antigen-specific CD4+ T cells become autoreactive after treatment with various DNA methylation inhibitors, including 5… (More)
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Highly Cited
1990
Highly Cited
1990
Evidence for impaired T cell DNA methylation in systemic lupus erythematosus and rheumatoid arthritis.
Procainamide and hydralazine inhibit T cell DNA methylation and induce autoreactivity in cloned CD4+ T cells. These drugs also… (More)
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Highly Cited
1988
Highly Cited
1988
Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.
Inhibitors of DNA methylation, such as 5-azacytidine, induce gene expression. We have previously reported that cloned T cells… (More)
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Highly Cited
1975
Highly Cited
1975
Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.
A new lidocaine derivative (Astra, GEA 968) depresses excitability of myelinated frog nerve in a manner which depends upon the… (More)
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