• Publications
  • Influence
Metabolism of clomiphene in the rat. Estrogen receptor affinity and antiestrogenic activity of clomiphene metabolites.
Incubation of the nonsteroidal antiestrogen clomiphene with rat liver microsomes resulted in the formation of the 4-hydroxy-, N-desethyl-, and N-oxide metabolites, in qualitative contrast to resultsExpand
  • 25
  • 1
Pharmacology of a new antiarrhythmic agent, gamma-diisopropyl-amino-alpha-phenyl-alpha-(2-pyridyl)-butyramide (SC-7031).
SC-7031 was effective at approximately ½ to ⅓ the effective dose of quinidine against certain cardiac arrhythmias in the dog. Atrial arrhythmias were reverted by intravenous closes of 5.8 ± 0.9 mg/kgExpand
  • 88
Estrogenic and antiestrogenic activity of monophenolic analogues of tamoxifen, (Z)-2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N, N-dimethylethylamine.
Five hydroxylated analogues of tamoxifen [1, (Z)-2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine] and its geometric isomer were prepared by reaction of protectedExpand
  • 43
Resolution, absolute configuration, and antiarrhythmic properties of the enantiomers of disopyramide, 4-(diisopropylamino)-2-(2-pyridyl)-2-phenylbutyramide.
Disopyramide was resolved by fractional crystallization of its diastereomeric bitartrate salts from methanol-acetone. Diastereomeric sulfonamides prepared from (+)-camphor-10-sulfonyl chloride andExpand
  • 33
Estrogen receptor binding and estrogenic/antiestrogenic effects of two new metabolites of nitromiphene, 2-[p-[2-nitro-1-(4-methoxyphenyl)-2-phenylvinyl]phenoxy]-N-ethylpyrrolidine.
Reduction of the triarylethylene antiestrogen 2-[p-[2-nitro-1-(4-methoxphenyl)-2-phenylvinyl]phenoxy]-N-ethylpyrrolidine (1) with sodium borohydride-stannous chloride affordedExpand
  • 8
Analogues of sparteine. 5. Antiarrhythmic activity of selected N,N'-disubstituted bispidines.
A series of seven N,N'-disubstituted bispidines, structurally analogous to the inner (B and C) rings of sparteine (1) and encompassing a range of lipophilicity in which 1 was centered, has beenExpand
  • 15
Antiarrhythmic activity of some N-alkylbispidinebenzamides.
A series of aromatic ring substituted bispidinebenzamides, 2--10, was prepared by condensation of N-methyl- or N-n-butylbispidine with the appropriate acid chlorides. These compounds were initiallyExpand
  • 8
Biotransformation of the antiestrogen clomiphene to chemically reactive metabolites in the immature female rat.
Novel metabolites of clomiphene (CLO), an antiestrogen effective in experimental breast cancer models, were characterized in studies using immature female rats. After i.p. administration, CLO wasExpand
  • 8
  • PDF
Subcellular distribution and incorporation of palmitate-U-14C into myocardial lipids: role of endogenous and exogenous catecholamines.
Abstract In order to assess the role played by exogenous catecholamine stores on the ability of cardiac muscle to incorporate palmitate-U- 14 C into tissue lipids, hearts from normal rabbits and fromExpand
  • 5