W. Seinen

Publications248
h-index50
Citations9,225
Highly Influential Citations361
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Determination of octanol/water partition coefficients for hydrophobic organic chemicals with the “slow‐stirring” method
Experimental data are presented on octanol/water partition coefficients for 70 hydrophobic organic chemicals that were determined with a “slow-stirring” method. With this method, log Kow values can…
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Guidance document of the scientific panel on genetically modified organisms for the risk assessment of genetically modified plants and derived food and feed: (Question No EFSA-Q-2003-005)
2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity?
TLDR
The observed induction of aromatase, the rate-limiting enzyme in the conversion of androgens to estrogens, may be an underlying explanation for some of the reported hormonal disrupting and tumor promoting properties of these herbicides in vivo.
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THE PHARMACOKINETICS OF GLYCYRRHIZIC ACID EVALUATED BY PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING†
TLDR
Physiologically based pharmacokinetic modeling indicated that the transit rate of gastrointestinal contents through the small and large intestines predominantly determines to what extent glycyrrhetic acid conjugates will be reabsorbed, which may serve as a useful risk estimator for glycyrrhizic-acid-induced adverse effects.
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Interaction of polycyclic musks and UV filters with the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) in reporter gene bioassays.
TLDR
The interaction of five polycyclic musk compounds and seven UV filters with the estrogen receptor, androgen receptor (AR), and progesterone (PR) receptor is assessed using sensitive and specific reporter gene cell lines to find out about the potential endocrine disrupting effects of these compounds in vivo.
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Measured pore-water concentrations make equilibrium partitioning work--a data analysis.
TLDR
The data analysis suggests that sediment bioaccumulation of compounds up to log K(ow) 7.5 in Tubificidae can be described as bioconcentration from pore-water, which implies that the risk assessment of sediment-associated HOCs can be significantly simplified.
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pH-DEPENDENT HYDROPHOBICITY OF THE CYANOBACTERIA TOXIN MICROCYSTIN-LR
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Estrogenic activity of UV filters determined by an in vitro reporter gene assay and an in vivo transgenic zebrafish assay
TLDR
The findings suggest that one should be aware of over-interpretation when predicting in vivo effects from weak in vitro data, and it can not be ruled out that these UV filters have long-term effects in the environment.
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Calf Intestinal Alkaline Phosphatase, a Novel Therapeutic Drug for Lipopolysaccharide (LPS)-Mediated Diseases, Attenuates LPS Toxicity in Mice and Piglets
TLDR
It is demonstrated that also alkaline phosphatase derived from calf intestine (CIAP) is able to detoxify LPS, and potentially encompasses a novel therapeutic agent in the treatment of LPS-mediated diseases.
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Dibutyltin and tributyltin compounds induce thymus atrophy in rats due to a selective action on thymic lymphoblasts.
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