• Publications
  • Influence
Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart
Silent information regulator (Sir)2, a class III histone deacetylase, mediates lifespan extension in model organisms and prevents apoptosis in mammalian cells. However, beneficial functions of Sir2Expand
  • 814
  • 59
Downregulation of MiR-199a Derepresses Hypoxia-Inducible Factor-1α and Sirtuin 1 and Recapitulates Hypoxia Preconditioning in Cardiac Myocytes
MicroRNAs are posttranscriptional gene regulators that are differentially expressed during various diseases and have been implicated in the underlying pathogenesis. We report here that miR-199a isExpand
  • 520
  • 28
Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress
Mammalian models of longevity are related primarily to caloric restriction and alterations in metabolism. We examined mice in which type 5 adenylyl cyclase (AC5) is knocked out (AC5 KO) and which areExpand
  • 297
  • 28
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.
Activation of mammalian sterile 20-like kinase 1 (Mst1) by genotoxic compounds is known to stimulate apoptosis in some cell types. The importance of Mst1 in cell death caused by clinically relevantExpand
  • 228
  • 25
Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure
A small molecule improves cardiac function by accelerating the transition of myosin into a force-producing state. Decreased cardiac contractility is a central feature of systolic heart failure.Expand
  • 325
  • 22
A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy
Thioredoxin 1 (Trx1) facilitates the reduction of signaling molecules and transcription factors by cysteine thiol-disulfide exchange, thereby regulating cell growth and death. Here we studied theExpand
  • 273
  • 20
Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.
The time relationship for recovery of mechanical function, the intramyocardial electrogram and coronary flow after brief periods of regional myocardial ischemia, was studied in conscious dogs. TotalExpand
  • 763
  • 18
Autophagy in chronically ischemic myocardium.
  • L. Yan, D. Vatner, +7 authors S. Vatner
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 27 September 2005
We tested the hypothesis that chronically ischemic (IS) myocardium induces autophagy, a cellular degradation process responsible for the turnover of unnecessary or dysfunctional organelles andExpand
  • 458
  • 14
Glycogen Synthase Kinase 3β Regulates GATA4 in Cardiac Myocytes*
Inactivation of glycogen synthase kinase 3β (GSK3β) is critical for transcription of atrial natriuretic factor (ANF) by β-adrenergic receptors in cardiac myocytes. We examined the mechanism by whichExpand
  • 224
  • 14
Silent Information Regulator 2&agr;, a Longevity Factor and Class III Histone Deacetylase, Is an Essential Endogenous Apoptosis Inhibitor in Cardiac Myocytes
Yeast silent information regulator 2 (Sir2), a nicotinamide adenine dinucleotide–dependent histone deacetylase (HDAC) and founding member of the HDAC class III family, functions in a wide array ofExpand
  • 285
  • 13