• Publications
  • Influence
Reference distributions for the negative acute‐phase serum proteins, albumin, transferrin and transthyretin: A practical, simple and clinically relevant approach in a large cohort
Inflammation is associated with diverse clinical conditions accompanied by characteristic changes in serum levels of the acute‐phase proteins that can be used to stage the inflammatory process andExpand
New international reference preparation for proteins in human serum (RPPHS).
TLDR
An overview on how the laboratory community, including manufacturers, clinical laboratories, professional societies, and regulators, has reached what they consider is a successful conclusion to a difficult problem is presented. Expand
Reference distributions for immunoglobulins A, G, and M: A practical, simple, and clinically relevant approach in a large cohort
TLDR
Using automated immunoassay values from 115,017 serum samples from northern New England patients to provide more reliable and comprehensive reference distributions for IgA, IgG, and IgM measurements enables interpretation of serum immunoglobulin measurements using a common unit (multiples of the median) that is independent of age or gender. Expand
Reference distributions for the negative acute‐phase proteins, albumin, transferrin, and transthyretin: A comparison of a large cohort to the world's literature
TLDR
This meta‐analysis provides support for the reliability of the recently published methodology and reference data for the clinical interpretation of individual albumin, transferrin, and transthyretin values. Expand
Background staining in immunoblot assays. Reduction of signal caused by cross-reactivity with blocking agents.
TLDR
As the primary antibody in these immunoblot assays was human IgG, human serum albumin was investigated as a blocking agent; this approach eliminated the problem of blocking-specific background. Expand
International Federation of Clinical Chemistry standardization project for measurements of apolipoproteins A-I and B.
TLDR
Relatively modest differences were found in calibration for apolipoprotein measurements among laboratories and methods, but very wide differences were observed for apo B methods. Expand
The clinical significance of titered antinuclear antibodies.
  • R. Ritchie
  • Medicine
  • Arthritis and rheumatism
  • 1 December 1967
Antinucleolar antibodies. Their frequency and diagnostic association.
  • R. Ritchie
  • Medicine
  • The New England journal of medicine
  • 21 May 1970
Collaborative calibration of the U. S. National and the College of American Pathologists reference preparations for specific serum proteins.
TLDR
The mean estimates of this study provide the most practical current consensus estimates of the “true” values for these analytes in these preparations, and can be used to provide an accuracy base to unify interlaboratory results. Expand
Reference distributions for complement proteins C3 and C4: A practical, simple and clinically relevant approach in a large cohort
The two serum proteins of the complement cascade in the highest concentrations, C3 and C4, respond to various conditions in much the same manner as do other positive acute‐phase proteins. A majorExpand
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