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Cloning and Functional Characterization of a Potential-sensitive, Polyspecific Organic Cation Transporter (OCT3) Most Abundantly Expressed in Placenta*
TLDR
A cDNA isolated from rat placenta which, when expressed heterologously, mediates the transport of a wide spectrum of organic cations, represents a new member of the OCT gene family. Expand
Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.
TLDR
It is shown that Gpr109a signaling promoted anti-inflammatory properties in colonic macrophages and dendritic cells and enabled them to induce differentiation of Treg cells and IL-10-producing T cells, and Niacr1(-/-) mice were susceptible to development of colonic inflammation and colon cancer. Expand
Human Intestinal H+/Peptide Cotransporter
TLDR
Ch Chromosomal assignment studies with somatic cell hybrid analysis and in situ hybridization have located the gene encoding the cloned human H+/peptide cotransporter to chromosome 13 q33→q34. Expand
Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation/carnitine transporter.
TLDR
It is demonstrated in the present study that novel organic cation transporter (OCTN) 2 is a transporter for organic cations as well as carnitine and that OCTN2 is expressed not only in the heart, kidney, and placenta but also in the brain. Expand
Sodium-coupled Monocarboxylate Transporters in Normal Tissues and in Cancer
TLDR
SLC5A8 also functions as a tumor suppressor; its expression is silenced in tumors of colon, thyroid, stomach, kidney, and brain, and the tumor-suppressive function is related to its ability to mediate concentrative uptake of butyrate, propionate, and pyruvate, all of which are inhibitors of histone deacetylases. Expand
Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond.
TLDR
This review focuses on three groups of nutrient transporters relevant to cancer: glucosetransporters, lactate transportters, and amino acid transporter, which are related to amino acid nutrition. Expand
High‐fat diet before and during pregnancy causes marked up‐regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice
TLDR
Data suggest that up‐regulation of specific placental nutrient transporter isoforms constitute a mechanism linking maternal high‐fat diet and obesity to fetal overgrowth in C57/BL6 mice. Expand
GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.
TLDR
It is shown that GPR109A mediates the tumor-suppressive effects of the bacterial fermentation product butyrate in colon and suppresses nuclear factor-kappaB activation in normal and cancer colon cell lines as well as in normal mouse colon. Expand
Cloning of the Human Thiamine Transporter, a Member of the Folate Transporter Family*
TLDR
A cDNA from human placenta is isolated, which, when expressed heterologously in mammalian cells, mediates the transport of the water-soluble vitamin thiamine and is most likely the gene defective in the metabolic disorder,Thiamine-responsive megaloblastic anemia. Expand
cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family.
TLDR
Cloned OCTN2, a new member of the organic cation transporter family, from a human placental trophoblast cell line, mediates the transport of tetraethylammonium in a pH-dependent manner and is more closely related to OCTN1 than to OCT1, OCT2 and OCT3. Expand
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