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Pirenzepine

Known as: 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-, Pyrenzepine, Pirenzepine [Chemical/Ingredient] 
An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central… 
National Institutes of Health

Related topics

Related topics

28 relations

Narrower (15)

4'-N-demethylolanzapineAFDX 384AQ-RA 721Bodipy-pirenzepine

Broader (5)

Anti-Ulcer AgentBenzodiazepinesBenzodiazepinonesEmetics
In BloodPirenzepine hydrochlorideagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1994
Highly Cited
1994
In vitro pharmacologic characterization of a cholinergic receptor on outer hair cells
Highly Cited
1991
Highly Cited
1991
Differential response of striatal dopamine and muscarinic cholinergic receptor subtypes to the loss of dopamine I. Effects of intranigral or intracerebroventricular 6-hydroxydopamine lesions of the…
Highly Cited
1991
Highly Cited
1991
Tonic cholinergic inhibition of spinal mechanical transmission
Highly Cited
1990
Highly Cited
1990
Muscarinic receptor activation facilitates the induction of long-term potentiation (LTP) in the rat dentate gyrus
Highly Cited
1989
Highly Cited
1989
Muscarinic receptor binding characteristics of a human neuroblastoma SK-N-SH and its clones SH-SY5Y and SH-EP1.
Highly Cited
1988
Highly Cited
1988
Muscarinic M1- and M2-receptors mediating opposite effects on neuromuscular transmission in rabbit vas deferens.
Highly Cited
1986
Highly Cited
1986
Binding profile of a novel cardioselective muscarine receptor antagonist, AF-DX 116, to membranes of peripheral tissues and brain in the rat.
Highly Cited
1986
Highly Cited
1986
Cardioselective profile of AF-DX 116, a muscarine M2 receptor antagonist.
Highly Cited
1985
Highly Cited
1985
Pirenzepine distinguishes between muscarinic receptor-mediated phosphoinositide breakdown and inhibition of adenylate cyclase.
Subtypes of muscarinic cholinergic receptors have been proposed to exist, but the biochemical responses mediated by the putative… 
Highly Cited
1985
Highly Cited
1985
Guanine nucleotide regulation of a mammalian myocardial muscarinic receptor system. Evidence for homo- and heterotropic cooperativity in ligand binding analyzed by computer-assisted curve fitting.
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