Pirenzepine

Known as: 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((4-methyl-1-piperazinyl)acetyl)-, Pyrenzepine, Pirenzepine [Chemical/Ingredient] 
An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central… (More)
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
OBJECTIVE To evaluate the safety and efficacy of the relatively selective M(1)-antagonist, pirenzepine ophthalmic gel (gel), in… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE To evaluate the safety and efficacy of the relatively selective M(1) antagonist pirenzepine hydrochloride in slowing… (More)
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Highly Cited
1999
Highly Cited
1999
In a slice preparation of rat visual cortex, we discovered that paired-pulse stimulation (PPS) elicits a form of homosynaptic… (More)
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1996
1996
PURPOSE To determine the efficacy of the M1-selective muscarinic antagonist, pirenzepine, in preventing experimentally induced… (More)
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1995
1995
Previous studies have demonstrated that muscarinic antagonists, such as atropine and pirenzepine, block form deprivation myopia… (More)
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Highly Cited
1995
Highly Cited
1995
Postsynaptic responses of dopamine (DA) neurons in the substantia nigra pars compacta (SNc) to stimulation of the… (More)
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Highly Cited
1988
Highly Cited
1988
The human and rat genes for a fifth muscarinic receptor have been cloned and expressed in mammalian cells. The 532 amino acid… (More)
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1987
1987
Two experiments were conducted to determine the effects of the M1 muscarinic receptor antagonist pirenzepine on place navigation… (More)
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Highly Cited
1987
Highly Cited
1987
Complementary DNAs for three different muscarinic acetylcholine receptors were isolated from a rat cerebral cortex library, and… (More)
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Highly Cited
1980
Highly Cited
1980
Some antagonists exhibit tissue selectivity in their pharmacological antagonism of muscarinic responses1. However, the affinity… (More)
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