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Nociceptor sensitization in pain pathogenesis
This work focuses here on nociceptors: their excitability, their heterogeneity and their role in initiating and maintaining pain.
Descending modulation of pain
  • G. Gebhart
  • Biology, Psychology
    Neuroscience & Biobehavioral Reviews
  • 31 January 2004
Mechanosensitive properties of pelvic nerve afferent fibers innervating the urinary bladder of the rat.
The response to UBD adapted slowly during the 20-s period of phasic UBD or during slow isotonic filling of the bladder, and the stimulus-response function of fibers to graded UBD was monotonic < or = 80 mmHg.
Splanchnic and pelvic mechanosensory afferents signal different qualities of colonic stimuli in mice.
The splanchnic and pelvic pathways contain distinct populations of mechanosensitive afferents, which are capable of detecting an array of mechanical stimuli and are individually tuned to detect the type, magnitude, and duration of the stimulus.