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Benzodiazepinones

Known as: Benzodiazepinones [Chemical/Ingredient] 
National Institutes of Health

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3-hydroxy-2-oxoquazepamAHN 086AdumbranBI-RJ 70
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Benzodiazepines
In Bloodagonistsantagonists & inhibitorschemical synthesis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Metal-free oxidative ring contraction of benzodiazepinones: an entry to quinoxalinones.
A novel and practical synthesis of 3-benzoylquinoxalin-2(1H)-ones from benzodiazepin-2-ones in two steps from commercially… 
2013
2013
Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain.
The IAPs are key regulators of the apoptotic pathways and are commonly overexpressed in many cancer cells. IAPs contain one to… 
2012
2012
Iridium catalyzed asymmetric hydrogenation of cyclic imines of benzodiazepinones and benzodiazepines.
Highly enantioselective Ir-catalyzed hydrogenation of seven-membered cyclic imines of benzodiazepinones and benzodiazepines was… 
Highly Cited
2011
Highly Cited
2011
1,3-Dipolar cycloaddition-decarboxylation reactions of an azomethine ylide with isatoic anhydrides: formation of novel benzodiazepinones.
A nonstabilized azomethine ylide reacts with a wide range of substituted isatoic anhydrides to afford novel 1,3-benzodiazepin-5… 
Highly Cited
2009
Highly Cited
2009
Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1*
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) is caused by many disease-relevant conditions, inducing… 
2009
2009
Combinatorial Library Synthesis and Biological Evaluation of Pyrazolo[4,3‐e][1,4]diazepine as a Potential Privileged Structure
A privileged structure: A library of tetrahydro‐1,4‐pyrazolo‐diazepin‐8(2H)‐ones was designed and synthesized to probe the… 
2007
2007
Discovery of (S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetamido)-N-((S,Z)-3-methyl-4-oxo-4,5-dihydro-3H-benzo[d][1,2]diazepin-5-yl)propanamide (BMS-433796): a gamma-secretase inhibitor with Abeta…
Highly Cited
2007
Highly Cited
2007
Polymeric sulfated amino acid surfactants: a class of versatile chiral selectors for micellar electrokinetic chromatography (MEKC) and MEKC-MS.
In this work, three amino acid-derived (l-leucinol, l-isoleucinol, l-valinol) sulfated chiral surfactants are synthesized and… 
1993
1993
Determination of the magnitude and enantioselectivity of ligand binding to rat and rabbit serum albumins using immobilized-protein high performance liquid chromatography stationary phases.
Review
1988
Review
1988
The story of flumazenil.
The story of flumazenil is a typical example of a serendipitous preclinical drug discovery. Our search for specific… 
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