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Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
The existence of adult heart-derived cardiac progenitor cells expressing stem cell antigen-1.5 is reported, and differentiation was shown to occur roughly equally, with and without fusion to host cells. Expand
The inflammatory response in myocardial infarction.
This review summarizes the current understanding of the cellular and molecular mechanisms regulating the inflammatory response following myocardial ischemia and reperfusion and concludes that by promoting more effective tissue repair, it may be possible to reduce the deleterious remodeling. Expand
Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells.
The results demonstrate the cardiomyogenic potential of hematopoietic stem cells and suggest a therapeutic strategy that eventually could benefit patients with myocardial infarction. Expand
Relative contribution of LFA-1 and Mac-1 to neutrophil adhesion and migration.
Genetic deficiencies demonstrate that both L FA-1 and Mac-1 contribute to adhesion of neutrophils to endothelial cells and ICAM-1, but adhesion through LFA-1 overshadows the contribution from Mac- 1. Expand
Reactive oxygen in skeletal muscle. II. Extracellular release of free radicals.
We have tested the hypothesis that diaphragm muscle fibers release superoxide anion radicals (O2-.) into the extracellular space. Fiber bundles were isolated from rat diaphragm and incubated inExpand
Resident cardiac mast cells degranulate and release preformed TNF-alpha, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion.
It is suggested that mast cell-derived TNF-alpha may be a crucial factor in upregulating IL-6 in infiltrating leukocytes and initiating the cytokine cascade responsible for myocyte ICAM-1 induction and subsequent neutrophil-induced injury. Expand
Myocardial ischemia and reperfusion: a murine model.
A mouse model to study coronary artery occlusion and reperfusion effects and the method required to perform these studies both acutely and chronically is developed, allowing assessment of AAR, IS, cardiac function, and pathophysiology in the mouse. Expand
LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice.
It is demonstrated that Mac-1 plays a critical role in mediating binding of neutrophils to fibrinogen and neutrophil degranulation, but is not necessary for effective neutrophIL emigration, which is more dependent upon LFA-1. Expand
Neutrophil transendothelial migration is independent of tight junctions and occurs preferentially at tricellular corners.
It appears that neutrophils preferentially migrate around endothelial tight junctions by crossing at tricellular corners rather than passing through the Tight junctions that lie between two endothelial cells. Expand
Mac-1 (CD11b/CD18) mediates adherence-dependent hydrogen peroxide production by human and canine neutrophils.
It is indicated that Mac-1 (CD11b/CD18) can mediate adhesion-dependent H2O2 production by human and canine neutrophils exposed to chemotactic factors. Expand