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Phospholipase C

Known as: phosphatidylcholine cholinephosphohydrolase, alpha-toxin, PLC 
An enzyme found in the alpha-toxin of Clostridium welchii and other strains of clostridia and bacilli. It hydrolyzes glycerophosphatidates with the… 
National Institutes of Health

Related topics

Related topics

13 relations
Basement Membrane-Specific Heparan Sulfate Proteoglycan Core ProteinHSPG2 wt AlleleInositol PhosphatesPLCB1 gene

Broader (3)

PhospholipaseType C Phospholipasesphosphoric diester hydrolase

Papers overview

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Highly Cited
2002
Highly Cited
2002
Effects of Dietary Fat Source and Subtherapeutic Levels of Antibiotic on the Bacterial Community in the Ileum of Broiler Chickens at Various Ages
ABSTRACT The effect of dietary fat source (soy oil or a mixture of lard and tallow) and dietary supplementation with antibiotics… 
Highly Cited
1997
Highly Cited
1997
Phospholipase C isozymes selectively couple to specific neurotransmitter receptors
A variety of extracellular signals are transduced across the cell membrane by the enzyme phosphoinositide-specific phospholipase… 
Highly Cited
1997
Highly Cited
1997
A site-directed Staphylococcus aureus hemB mutant is a small-colony variant which persists intracellularly
Although small-colony variants (SCVs) of Staphylococcus aureus have been recognized for many years, this phenotype has only… 
Highly Cited
1995
Highly Cited
1995
Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain
Highly Cited
1991
Highly Cited
1991
PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254
Highly Cited
1989
Highly Cited
1989
Receptor-coupled, permeabilized smooth muscle. Role of the phosphatidylinositol cascade, G-proteins, and modulation of the contractile response to Ca2+.
alpha-Adrenergic (phenylephrine) and muscarinic (carbachol) agonists and inositol 1,4,5-trisphosphate caused calcium release and… 
Highly Cited
1989
Highly Cited
1989
High-resolution (1.5 Å) crystal structure of phospholipase C from Bacillus cereus
BOTH the phosphatidylinositol-hydrolysing and the phos-phatidylcholine-hydrolysing phospholipases C have been implicated in the… 
Highly Cited
1986
Highly Cited
1986
Phospholipase A2 and phospholipase C are activated by distinct GTP-binding proteins in response to alpha 1-adrenergic stimulation in FRTL5 thyroid cells.
In FRTL5 rat thyroid cells, norepinephrine, by interacting with alpha 1-adrenergic receptors, stimulates inositol phosphate… 
Highly Cited
1986
Highly Cited
1986
Escherichia coli hemolysin may damage target cell membranes by generating transmembrane pores
Escherichia coli hemolysin is secreted as a water-soluble polypeptide of Mr 107,000. After binding to target erythrocytes, the… 
Highly Cited
1981
Highly Cited
1981
On the mechanism of membrane damage by Staphylococcus aureus alpha- toxin
Rabbit or human erythrocytes lysed with Staphylococcus aureus alpha- toxin were solubilized with Triton X-100, and the toxin was… 
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