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Phospholipase C

Known as: phosphatidylcholine cholinephosphohydrolase, alpha-toxin, PLC 
An enzyme found in the alpha-toxin of Clostridium welchii and other strains of clostridia and bacilli. It hydrolyzes glycerophosphatidates with the… 
National Institutes of Health

Related topics

Related topics

13 relations
Basement Membrane-Specific Heparan Sulfate Proteoglycan Core ProteinHSPG2 wt AlleleInositol PhosphatesPLCB1 gene

Broader (3)

PhospholipaseType C Phospholipasesphosphoric diester hydrolase

Papers overview

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Highly Cited
1997
Highly Cited
1997
A close association of GM3 with c-Src and Rho in GM3-enriched microdomains at the B16 melanoma cell surface membrane: a preliminary note.
B16 melanoma is characterized by high content of GM3 ganglioside, which has been recognized as a melanoma-associated antigen… 
Highly Cited
1994
Highly Cited
1994
Evidence for retrograde traffic between terminal lysosomes and the prelysosomal/late endosome compartment.
We have investigated the interactions occurring between the prelysosomal compartment, PLC/late endosome, and terminal lysosomes… 
Highly Cited
1991
Highly Cited
1991
CD3 stimulation causes phosphorylation of phospholipase C-gamma 1 on serine and tyrosine residues in a human T-cell line.
The human T-cell line Jurkat was found to contain at least two immunologically distinct isoforms of inositol phospholipid… 
Highly Cited
1989
Highly Cited
1989
Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.
Epidermal growth factor (EGF) rapidly stimulates the formation of inositol 1,4,5-trisphosphate in a variety of cell types… 
Highly Cited
1988
Highly Cited
1988
Bacterial exotoxins and endothelial permeability for water and albumin in vitro.
Effects of Staphylococcus aureus alpha-toxin and Pseudomonas aeruginosa cytotoxin on the permeability of an endothelial monolayer… 
Highly Cited
1985
Highly Cited
1985
Secondary structure and assembly mechanism of an oligomeric channel protein.
The alpha-toxin of Staphylococcus aureus is secreted as a water-soluble, monomeric polypeptide (Mr 33 182) that can assemble into… 
Highly Cited
1980
Highly Cited
1980
The relationship between agonist occupation and the permeability response of the cholinergic receptor revealed by bound cobra alpha-toxin.
Highly Cited
1979
Highly Cited
1979
Irreversible thiophosphorylation and activation of tension in functionally skinned rabbit ileum strips by [35S]ATP gamma S.
Rabbit ileum strips were functionally skinned by exposure to staphylococcal alpha-toxin. Incubation of the strips in the ATP… 
Highly Cited
1978
Highly Cited
1978
Membranes rich in acetylcholine receptor: characterization and reconstitution to excitable membranes from exogenous lipids.
Characterization of acetylcholine-receptor-enriched membranes from Torpedo californica electric tissue by negative-staining… 
Highly Cited
1968
Highly Cited
1968
Studies on the phospholipid requirement of glucose 6-phosphatase.
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