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Phospholipase C

Known as: phosphatidylcholine cholinephosphohydrolase, alpha-toxin, PLC 
An enzyme found in the alpha-toxin of Clostridium welchii and other strains of clostridia and bacilli. It hydrolyzes glycerophosphatidates with the… 
National Institutes of Health

Related topics

Related topics

13 relations
Basement Membrane-Specific Heparan Sulfate Proteoglycan Core ProteinHSPG2 wt AlleleInositol PhosphatesPLCB1 gene

Broader (3)

PhospholipaseType C Phospholipasesphosphoric diester hydrolase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Ionic channels formed byStaphylococcus aureus alpha-toxin: Voltage-dependent inhibition by divalent and trivalent cations
SummaryThe interaction ofStaphylococcus aureus α-toxin with planar lipid membranes results in the formation of ionic channels… 
Highly Cited
2002
Highly Cited
2002
Inhibition of PTPs by H(2)O(2) regulates the activation of distinct MAPK pathways.
Highly Cited
2001
Highly Cited
2001
mGluR1-mediated potentiation of NMDA receptors involves a rise in intracellular calcium and activation of protein kinase C
Highly Cited
1999
Highly Cited
1999
Actin polymerization stimulated by contractile activation regulates force development in canine tracheal smooth muscle
1 The role of actin polymerization in the regulation of smooth muscle contractility was investigated in canine trachealis muscle… 
Highly Cited
1991
Highly Cited
1991
Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1.
Stimulation of the T-cell antigen receptor (TCR), which itself is not a protein-tyrosine kinase (PTK), activates a PTK and… 
Review
1990
Review
1990
Recent insights in phosphatidylinositol signaling
Highly Cited
1989
Highly Cited
1989
Receptor-coupled, permeabilized smooth muscle. Role of the phosphatidylinositol cascade, G-proteins, and modulation of the contractile response to Ca2+.
alpha-Adrenergic (phenylephrine) and muscarinic (carbachol) agonists and inositol 1,4,5-trisphosphate caused calcium release and… 
Highly Cited
1989
Highly Cited
1989
Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.
Epidermal growth factor (EGF) rapidly stimulates the formation of inositol 1,4,5-trisphosphate in a variety of cell types… 
Highly Cited
1989
Highly Cited
1989
Direct regulation of smooth muscle contractile elements by second messengers.
Highly Cited
1977
Highly Cited
1977
Action of highly purified phospholipases on blood platelets. Evidence for an asymmetric distribution of phospholipids in the surface membrane.
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