Phosphatidylinositols

Known as: Phospholipids, Inositide, inositol phospholipid, Phosphoglycerides, Inositol 
A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide. It… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires… (More)
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Review
2002
Review
2002
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation… (More)
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Highly Cited
2000
Highly Cited
2000
The specificities of 28 commercially available compounds reported to be relatively selective inhibitors of particular serine… (More)
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Highly Cited
1998
Highly Cited
1998
Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) is a key molecule involved in cell growth signaling. We demonstrated… (More)
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Highly Cited
1998
Highly Cited
1998
Protein kinase B (PKB) is activated in response to phosphoinositide 3-kinases and their lipid products phosphatidylinositol 3,4… (More)
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Highly Cited
1997
Highly Cited
1997
The regulation of the serine-threonine kinase Akt by lipid products of phosphoinositide 3-kinase (PI 3-kinase) was investigated… (More)
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Highly Cited
1997
Highly Cited
1997
Protein kinase B (PKB) is a proto-oncogene that is activated in signaling pathways initiated by phosphoinositide 3-kinase… (More)
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Highly Cited
1994
Highly Cited
1994
Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor… (More)
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Highly Cited
1993
Highly Cited
1993
The yeast TOR2 gene encodes an essential 282 kd phosphatidylinositol (PI) 3-kinase homolog. TOR2 is related to the catalytic… (More)
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Highly Cited
1988
Highly Cited
1988
The generation of second messengers from the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdInsP2) by phospho… (More)
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