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Phosphatidylinositols

Known as: Phospholipids, Inositide, inositol phospholipid, Phosphoglycerides, Inositol 
A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide. It… 
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and diabetes. Akt/PKB activation requires… 
Review
2001
Review
2001
Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and… 
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Highly Cited
1998
Highly Cited
1998
Phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) is a key molecule involved in cell growth signaling. We demonstrated… 
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Highly Cited
1997
Highly Cited
1997
BAD is a distant member of the Bcl-2 family that promotes cell death. Phosphorylation of BAD prevents this. BAD phosphorylation… 
Review
1995
Review
1995
A number of different intracellular signaling pathways have been shown to be activated by receptor tyrosine kinases. These… 
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Highly Cited
1994
Highly Cited
1994
Phosphatidylinositol (PtdIns) 3-kinase is an enzyme implicated in growth factor signal transduction by associating with receptor… 
Highly Cited
1993
Highly Cited
1993
MAINTENANCE of a stable internal environment within complex organisms requires specialized cells that sense changes in the… 
Review
1992
Review
1992
Hydrolysis of inositol phospholipids by phospholipase C is initiated by either receptor stimulation or opening of Ca2+ channels… 
Review
1986
Review
1986
Protein kinase C, an enzyme that is activated by the receptor-mediated hydrolysis of inositol phospholipids, relays information… 
Review
1984
Review
1984
Protein kinase C has a crucial role in signal transduction for a variety of biologically active substances which activate…