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Svp1p defines a family of phosphatidylinositol 3,5‐bisphosphate effectors
TLDR
Svp1p is identified as a PtdIns(3,5)P2 effector required for Ptdins 3,5‐bisphosphate recycling from the vacuole, and it is likely that many of the SVP1p‐related proteins that are ubiquitous throughout the eukaryotes are Ptd insurance effectors.
Phosphoinositide signalling links O-GlcNAc transferase to insulin resistance
TLDR
It is shown that O-GlcNAc transferase (OGT) harbours a previously unrecognized type of phosphoinositide-binding domain, which underscores the contribution of this modification to the aetiology of insulin resistance and type 2 diabetes.
Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis
TLDR
It is shown that when the yeasts Saccharomyces cerevisiae and SchizosacCharomyces pombe are hyperosmotically stressed, they rapidly synthesize phosphatidylinositol-3,5-bisphosphate (PtdIns( 3,5)P2) by a process that involves activation of a PtdIns3P 5-OH kinase.
Inositol phospholipids and cell surface receptor function.
  • R. Michell
  • Biology
    Biochimica et biophysica acta
  • 25 March 1975
Inositol derivatives: evolution and functions
  • R. Michell
  • Biology
    Nature Reviews Molecular Cell Biology
  • 1 February 2008
Current research on inositols mainly focuses on myo-inositol (Ins) derivatives in eukaryotic cells, and in particular on the many roles of Ins phospholipids and polyphosphorylated Ins derivatives.
Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function.
TLDR
Recent studies that reveal the role of the HOPS-CORVET complex and the vacuolar H(+)-ATPase in the process of endo-lysosome fission are highlighted and connections between these machineries and the Fab1p pathway are speculated on.
PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49.
TLDR
It is concluded that WIPI49 is a novel regulatory component of the endosomal and MPR pathway and that this role is dependent upon the PI-binding properties of its WD40 domain.
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