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Phosphatidylinositol-3-OH kinase direct target of Ras
Ras (p21ras) interacts directly with the catalytic subunit of phosphatidylinositol-3-OH kinase in a GTP-dependent manner through the Ras effector site. In vivo, dominant negative Ras mutant N17Expand
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Synthesis and function of 3-phosphorylated inositol lipids.
The 3-phosphorylated inositol lipids fulfill roles as second messengers by interacting with the lipid binding domains of a variety of cellular proteins. Such interactions can affect the subcellularExpand
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The emerging mechanisms of isoform-specific PI3K signalling
Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal transduction pathways and affect many biological functions. A further level of complexity derives from the existence of eightExpand
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The PI3K-PDK1 connection: more than just a road to PKB.
Phosphoinositide 3-kinases (PI3Ks) generate specific inositol lipids that have been implicated in the regulation of cell growth, proliferation, survival, differentiation and cytoskeletal changes. OneExpand
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Phosphoinositide 3-kinases: a conserved family of signal transducers.
Phosphoinositide 3-kinases (PI3Ks) generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane traffic. Several distinct classes of PI3Ks have now beenExpand
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Signaling by distinct classes of phosphoinositide 3-kinases.
Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K) enzymes whose inositol lipid products are key mediators of intracellular signaling. Different PI3K isoforms generateExpand
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Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice
Class IA phosphoinositide 3-kinases (PI3Ks) are a family of p85/p110 heterodimeric lipid kinases that generate second messenger signals downstream of tyrosine kinases, thereby controlling cellExpand
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PI3K signalling: the path to discovery and understanding
Over the past two decades, our understanding of phospoinositide 3-kinases (PI3Ks) has progressed from the identification of an enzymatic activity associated with growth factors, GPCRs and certainExpand
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PI3K in lymphocyte development, differentiation and activation
Phosphoinositide 3-kinases (PI3Ks) regulate numerous biological processes, including cell growth, differentiation, survival, proliferation, migration and metabolism. In the immune system, impairedExpand
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Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation.
We have reported previously that Ras interacts with the catalytic subunit of phosphoinositide 3‐kinase (PI 3‐kinase) in a GTP‐dependent manner. The affinity of the interaction of Ras‐GTP withExpand
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