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- Publications
- Influence
Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1*
- M. Tanno, J. Sakamoto, T. Miura, K. Shimamoto, Y. Horio
- Biology, Medicine
- Journal of Biological Chemistry
- 2 March 2007
Sir2 (silent information regulator 2) is an NAD+-dependent histone deacetylase that contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones and various… Expand
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2014)
- K. Shimamoto, K. Ando, +37 authors S. Umemura
- Medicine
- Hypertension Research
- 2014
Kazuaki SHIMAMOTO, Katsuyuki ANDO, Toshiro FUJITA, Naoyuki HASEBE, Jitsuo HIGAKI, Masatsugu HORIUCHI, Yutaka IMAI, Tsutomu IMAIZUMI, Toshihiko ISHIMITSU, Masaaki ITO, Sadayoshi ITO, Hiroshi ITOH,… Expand
Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure*
- M. Tanno, A. Kuno, +5 authors Y. Horio
- Biology, Medicine
- The Journal of Biological Chemistry
- 20 January 2010
Oxidative stress plays a pivotal role in chronic heart failure. SIRT1, an NAD+-dependent histone/protein deacetylase, promotes cell survival under oxidative stress when it is expressed in the… Expand
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009)
- T. Ogihara, K. Kikuchi, +27 authors H. Rakugi
- Medicine
- Hypertension Research
- 1 December 2009
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009)
Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection.
- M. Nishihara, T. Miura, +7 authors K. Shimamoto
- Biology, Medicine
- Journal of molecular and cellular cardiology
- 1 November 2007
Recently we found that the level of anti-infarct tolerance afforded by ischemic preconditioning (IPC) and erythropoietin (EPO) infusion was closely correlated with the level of Ser9-phospho-GSK-3beta… Expand
Clinical implications of midventricular obstruction and intravenous propranolol use in transient left ventricular apical ballooning (Tako-tsubo cardiomyopathy).
- T. Yoshioka, A. Hashimoto, +11 authors K. Shimamoto
- Medicine
- American heart journal
- 1 March 2008
BACKGROUND
Persistent hypotension with dynamic midventricular obstruction (MVO) in patients with transient left ventricular (LV) apical ballooning (Tako-tsubo cardiomyopathy) is an important… Expand
Genome-wide association study of coronary artery disease in the Japanese
- F. Takeuchi, M. Yokota, +22 authors N. Kato
- Biology, Medicine
- European Journal of Human Genetics
- 1 March 2012
A new understanding of the genetic basis of coronary artery disease (CAD) has recently emerged from genome-wide association (GWA) studies of common single-nucleotide polymorphisms (SNPs), thus far… Expand
Target Blood Pressure for Treatment of Isolated Systolic Hypertension in the Elderly: Valsartan in Elderly Isolated Systolic Hypertension Study
- T. Ogihara, T. Saruta, +11 authors H. Ueshima
- Medicine
- Hypertension
- 1 August 2010
In this prospective, randomized, open-label, blinded end point study, we aimed to establish whether strict blood pressure control (<140 mm Hg) is superior to moderate blood pressure control (≥140 mm… Expand
Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases
- M. Furuhashi, S. Saitoh, K. Shimamoto, T. Miura
- Medicine
- Clinical Medicine Insights. Cardiology
- 1 January 2014
Over the past decade, evidences of an integration of metabolic and inflammatory pathways, referred to as metaflammation in several aspects of metabolic syndrome, have been accumulating. Fatty… Expand
Executive summary of Japan Atherosclerosis Society (JAS) guideline for diagnosis and prevention of atherosclerotic cardiovascular diseases for Japanese.
- T. Teramoto, J. Sasaki, +9 authors M. Yokode
- Medicine
- Journal of atherosclerosis and thrombosis
- 1 April 2007