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- Publications
- Influence
Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1*
- M. Tanno, J. Sakamoto, T. Miura, K. Shimamoto, Y. Horio
- Biology, Medicine
- Journal of Biological Chemistry
- 2 March 2007
Sir2 (silent information regulator 2) is an NAD+-dependent histone deacetylase that contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones and various… Expand
Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure*
- M. Tanno, A. Kuno, +5 authors Y. Horio
- Biology, Medicine
- The Journal of Biological Chemistry
- 20 January 2010
Oxidative stress plays a pivotal role in chronic heart failure. SIRT1, an NAD+-dependent histone/protein deacetylase, promotes cell survival under oxidative stress when it is expressed in the… Expand
Regulation by Orexin of Feeding Behaviour and Locomotor Activity in the Goldfish
- T. Nakamachi, K. Matsuda, +5 authors S. Shioda
- Biology, Medicine
- Journal of neuroendocrinology
- 1 April 2006
Orexin is a hypothalamic neuropeptide that is implicated in the regulation of feeding behaviour and the sleep‐wakefulness cycle in mammals. However, in spite of a growing body of knowledge concerning… Expand
Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning
- T. Miki, Takahito Itoh, Daisuke Sunaga, T. Miura
- Medicine
- Cardiovascular Diabetology
- 13 June 2012
In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. Myocardial… Expand
Diabetic cardiomyopathy: pathophysiology and clinical features
Since diabetic cardiomyopathy was first reported four decades ago, substantial information on its pathogenesis and clinical features has accumulated. In the heart, diabetes enhances fatty acid… Expand
Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection.
- M. Nishihara, T. Miura, +7 authors K. Shimamoto
- Biology, Medicine
- Journal of molecular and cellular cardiology
- 1 November 2007
Recently we found that the level of anti-infarct tolerance afforded by ischemic preconditioning (IPC) and erythropoietin (EPO) infusion was closely correlated with the level of Ser9-phospho-GSK-3beta… Expand
Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases
- M. Furuhashi, S. Saitoh, K. Shimamoto, T. Miura
- Medicine
- Clinical Medicine Insights. Cardiology
- 1 January 2014
Over the past decade, evidences of an integration of metabolic and inflammatory pathways, referred to as metaflammation in several aspects of metabolic syndrome, have been accumulating. Fatty… Expand
Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy
- Y. Hori, A. Kuno, +4 authors Y. Horio
- Biology, Medicine
- Journal of Pharmacology and Experimental…
- 1 September 2011
Muscular dystrophies are inherited myogenic disorders accompanied by progressive skeletal muscle weakness and degeneration. We previously showed that resveratrol (3,5,4′-trihydroxy-trans-stilbene),… Expand
Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischemic heart disease: clinical trial and preliminary results.
- K. Hamano, M. Nishida, +6 authors K. Esato
- Medicine
- Japanese circulation journal
- 28 March 2001
A new therapy for severe ischemic heart disease has been developed; therapeutic angiogenesis induced by the local implantation of autologous bone marrow cells (BMC). After confirming that no… Expand
Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery
- D. Hausenloy, J. Barrabés, +27 authors D. Garcia-Dorado
- Medicine
- Basic Research in Cardiology
- 20 October 2016
To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the history of IPC,… Expand