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Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1*

Findings indicate that nucleocytoplasmic shuttling is a novel regulatory mechanism of SIRT1, which may participate in differentiation and in inhibition of cell death.
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Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure*

Oral administration of resveratrol to TO-2 hamsters increased Mn-SOD levels in cardiomyocytes, suppressed fibrosis, preserved cardiac function, and significantly improved survival, suggesting SIRT1 activators such as resver atrol could be novel therapeutic tools for the treatment of chronic heart failure.
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Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker.

In contrast with other antihypertensive drugs, olmesartan may uniquely increase urinary ACE2 level, which could potentially offer additional renoprotective effects.
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Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases

Both the significant role of FABP4 in pathophysiological insights and its usefulness as a biomarker of metabolic and cardiovascular diseases are discussed.
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Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning

Observations of the effects of DM on myocardial infarct size and ischemic PC and PostC are summarized and perspectives for protection of DM hearts are discussed.
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Diabetic cardiomyopathy: pathophysiology and clinical features

Circumstantial evidence to date indicates that diabetic cardiomyopathy is a common but frequently unrecognized pathological process in asymptomatic diabetic patients, but a strategy for prevention or treatment to improve its prognosis has not yet been established.
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Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection.

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Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy

Findings indicate that SIRT1 activation may be a useful strategy for treating muscular dystrophies.
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Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery

An overview of the major topics discussed at this special meeting of leading pioneers in the field of cardioprotection to review and discuss the history of IPC, its evolution to IPost and RIC, myocardial reperfusion injury as a therapeutic target, and future targets and strategies for cardioprotsection is provided.
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Strain rate imaging for noninvasive functional quantification of the left atrium: comparative studies in controls and patients with atrial fibrillation.

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