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Nucleocytoplasmic Shuttling of the NAD+-dependent Histone Deacetylase SIRT1*
Sir2 (silent information regulator 2) is an NAD+-dependent histone deacetylase that contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones and variousExpand
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Induction of Manganese Superoxide Dismutase by Nuclear Translocation and Activation of SIRT1 Promotes Cell Survival in Chronic Heart Failure*
Oxidative stress plays a pivotal role in chronic heart failure. SIRT1, an NAD+-dependent histone/protein deacetylase, promotes cell survival under oxidative stress when it is expressed in theExpand
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Regulation by Orexin of Feeding Behaviour and Locomotor Activity in the Goldfish
Orexin is a hypothalamic neuropeptide that is implicated in the regulation of feeding behaviour and the sleep‐wakefulness cycle in mammals. However, in spite of a growing body of knowledge concerningExpand
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Effects of diabetes on myocardial infarct size and cardioprotection by preconditioning and postconditioning
In spite of the current optimal therapy, the mortality of patients with ischemic heart disease (IHD) remains high, particularly in cases with diabetes mellitus (DM) as a co-morbidity. MyocardialExpand
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Diabetic cardiomyopathy: pathophysiology and clinical features
Since diabetic cardiomyopathy was first reported four decades ago, substantial information on its pathogenesis and clinical features has accumulated. In the heart, diabetes enhances fatty acidExpand
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Modulation of the mitochondrial permeability transition pore complex in GSK-3beta-mediated myocardial protection.
Recently we found that the level of anti-infarct tolerance afforded by ischemic preconditioning (IPC) and erythropoietin (EPO) infusion was closely correlated with the level of Ser9-phospho-GSK-3betaExpand
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Fatty Acid-Binding Protein 4 (FABP4): Pathophysiological Insights and Potent Clinical Biomarker of Metabolic and Cardiovascular Diseases
Over the past decade, evidences of an integration of metabolic and inflammatory pathways, referred to as metaflammation in several aspects of metabolic syndrome, have been accumulating. FattyExpand
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Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy
  • Y. Hori, A. Kuno, +4 authors Y. Horio
  • Biology, Medicine
  • Journal of Pharmacology and Experimental…
  • 1 September 2011
Muscular dystrophies are inherited myogenic disorders accompanied by progressive skeletal muscle weakness and degeneration. We previously showed that resveratrol (3,5,4′-trihydroxy-trans-stilbene),Expand
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Local implantation of autologous bone marrow cells for therapeutic angiogenesis in patients with ischemic heart disease: clinical trial and preliminary results.
A new therapy for severe ischemic heart disease has been developed; therapeutic angiogenesis induced by the local implantation of autologous bone marrow cells (BMC). After confirming that noExpand
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Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery
To commemorate the auspicious occasion of the 30th anniversary of IPC, leading pioneers in the field of cardioprotection gathered in Barcelona in May 2016 to review and discuss the history of IPC,Expand
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