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Phorbols

Known as: Phorbols [Chemical/Ingredient], phorbol 
The parent alcohol of the tumor promoting compounds from CROTON OIL (Croton tiglium).
National Institutes of Health

Related topics

Related topics

19 relations

Narrower (12)

14-deoxylactucinPhorbolPhorbol EstersTetradecanoylphorbol Acetate

Broader (3)

CarcinogensDiterpenesTumor Promoters
Croton Oilaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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Highly Cited
1987
Highly Cited
1987
Contraction of rat thoracic aorta strips induced by phorbol 12-myristate 13-acetate.
Phorbol 12-myristate 13-acetate (PMA) induced a slow and progressive increase in tension of rat thoracic aorta strips in the… 
1987
1987
Comparison of subcellular activation of the human neutrophil NADPH-oxidase by arachidonic acid, sodium dodecyl sulfate (SDS), and phorbol myristate acetate (PMA).
The phorbol myristate acetate (PMA) stimulation of the human neutrophil NADPH-oxidase has been demonstrated through the… 
1986
1986
Formation of a phorbol ester-binding fragment from protein kinase C by proteolytic digestion.
When washed human platelets were disrupted by sonication in the presence of ethylene glycol bis(beta-aminoethyl ether)-N,N,N',N… 
Highly Cited
1986
Highly Cited
1986
Rapid assay of binding of tumor-promoting phorbol esters to protein kinase C1.
Protein kinase C is generally accepted to be a receptor protein of tumor-promoting phorbol esters. The binding of [3H]phorbol-12… 
Highly Cited
1986
Highly Cited
1986
Involvement of protein kinase C in the regulation of adrenocorticotropin release from rat anterior pituitary cells.
The involvement of protein kinase C in normal corticotroph function was studied by analysis of the effects of the phorbol ester… 
1984
1984
Differential phosphorylation events associated with phorbol ester effects on acceleration versus inhibition of cell growth.
Phorbol-12-myristate-13-acetate (PMA) in some systems causes inhibition of growth; in others, PMA exerts a mitogenic effect. We… 
1983
1983
Solubilization, purification, and reconstitution of a phorbol ester receptor from the particulate protein fraction of mouse brain.
The protein that specifically binds 12-O-[3H]tetradecanoyl-phorbol-13-acetate was solubilized from mouse brain particulate… 
Highly Cited
1981
Highly Cited
1981
Tumor-promoting phorbol diester-induced specific changes in cell surface glycoprotein profile of K562 human leukemic cells.
The tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA), induced specific changes in the cell surface… 
Highly Cited
1981
Highly Cited
1981
Tissue and species distribution and developmental variation of specific receptors for biologically active phorbol and ingenol esters.
A new and rapid binding assay for [3H]phorbol-12,13-dibutyrate (PDBu) binding to its receptors in cell or tissue homogenates or… 
1974
1974
Lack of an effect of tumor-promoting phorbol esters and of epidermal G1 chalone or DNA synthesis in the epidermis of newborn mice.
Summary An investigation was carried out on the effect of skin and epidermis fractions containing epidermal G 1 chalone and of…