Phorbols

Known as: Phorbols [Chemical/Ingredient], phorbol 
The parent alcohol of the tumor promoting compounds from CROTON OIL (Croton tiglium).
National Institutes of Health

Papers overview

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Review
2007
Review
2007
Phorbol esters are the tetracyclic diterpenoids generally known for their tumor promoting activity. The phorbol esters mimic the… (More)
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Highly Cited
2004
Highly Cited
2004
Tuberous sclerosis complex (TSC) is a genetic disorder caused by mutations in either of the two tumor suppressor genes TSC1 or… (More)
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Highly Cited
2002
Highly Cited
2002
We have studied activation by phorbol derivatives of TRPV4 channels, the human VRL-2, and murine TRP12 channels, which are highly… (More)
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Highly Cited
1998
Highly Cited
1998
We determined whether resveratrol, a phenolic antioxidant found in grapes and other food products, inhibited phorbol ester (PMA… (More)
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Highly Cited
1998
Highly Cited
1998
Munc13-1, a mammalian homolog of C. elegans unc-13p, is thought to be involved in the regulation of synaptic transmission. We now… (More)
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Highly Cited
1997
Highly Cited
1997
The chemokine receptor CXCR4 is required, together with CD4, for entry by some isolates of HIV-1, particularly those that emerge… (More)
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Highly Cited
1986
Highly Cited
1986
Protein kinase C (PKC), a calcium-dependent phospholipid-sensitive kinase which is selectively activated by phorbol esters, is… (More)
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Highly Cited
1983
Highly Cited
1983
Although the biochemical mechanism of action of phorbol ester tumour promoters is not fully understood, it is known that phorbol… (More)
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Highly Cited
1983
Highly Cited
1983
The phorbol diester receptor present in the particulate fraction of rat brain was solubilized by divalent ion chelation in the… (More)
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Highly Cited
1979
Highly Cited
1979
When suspension cultures of human promyelocytic leukemia cells (line HL60) were treated with 12-O-tetradecanoylphorbol 13-acetate… (More)
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