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Phorbols

Known as: Phorbols [Chemical/Ingredient], phorbol 
The parent alcohol of the tumor promoting compounds from CROTON OIL (Croton tiglium).
National Institutes of Health

Related topics

Related topics

19 relations

Narrower (12)

14-deoxylactucinPhorbolPhorbol EstersTetradecanoylphorbol Acetate

Broader (3)

CarcinogensDiterpenesTumor Promoters
Croton Oilaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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Highly Cited
1993
Highly Cited
1993
Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase.
Phorbol ester tumor promoters (TPA) activate the endogenous erk/MAP kinases and Rsk S6 kinases but not the p70S6 kinase in COS… 
Highly Cited
1987
Highly Cited
1987
Contraction of rat thoracic aorta strips induced by phorbol 12-myristate 13-acetate.
Phorbol 12-myristate 13-acetate (PMA) induced a slow and progressive increase in tension of rat thoracic aorta strips in the… 
Highly Cited
1987
Highly Cited
1987
Human T lymphocyte activation by tumor promoters: role of protein kinase C.
Protein kinase C (PKC) has a major role in a ligand-receptor-mediated signal transduction system in a variety of cell types… 
Highly Cited
1986
Highly Cited
1986
Reorganization of alpha-actinin and vinculin induced by a phorbol ester in living cells
We have used fluorescent analogue cytochemistry, image intensification, and digital image processing to examine the… 
1983
1983
Solubilization, purification, and reconstitution of a phorbol ester receptor from the particulate protein fraction of mouse brain.
The protein that specifically binds 12-O-[3H]tetradecanoyl-phorbol-13-acetate was solubilized from mouse brain particulate… 
Highly Cited
1982
Highly Cited
1982
Acute and progressive lung injury after contact with phorbol myristate acetate.
Because of its potent ability to activate leukocytes and macrophages, resulting in the generation of large amounts of oxygen… 
1981
1981
Induction of specific protein synthesis by phorbol esters in mouse epidermal cell culture.
The induction of specific protein synthesis by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), was studied in… 
Highly Cited
1977
Highly Cited
1977
Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.
Summary Topical application of retinoic acid to mouse skin led to a dramatic inhibition of phorbol ester (12- O -tetradecanoyl… 
Highly Cited
1977
Highly Cited
1977
Effect of phorbol myristate acetate on the recovery of spontaneous and ultraviolet light-induced 6-thioguanine and ouabain-resistant Chinese hamster cells.
12-0-Tetradecanoyl-phorbol-13-acetate (TPA) and phorbol were tested in Chinese hamster cells for their effects on mutagenesis… 
Highly Cited
1974
Highly Cited
1974
Membrane effects of phorbol esters.
Tetradecanoyl-phorbol-acetate (TPA) was observed to produce a 15% decrease in the electrophoretic mobility of hyperdiploid… 
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