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Phorbols

Known as: Phorbols [Chemical/Ingredient], phorbol 
The parent alcohol of the tumor promoting compounds from CROTON OIL (Croton tiglium).
National Institutes of Health

Related topics

Related topics

19 relations

Narrower (12)

14-deoxylactucinPhorbolPhorbol EstersTetradecanoylphorbol Acetate

Broader (3)

CarcinogensDiterpenesTumor Promoters
Croton Oilaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1992
Highly Cited
1992
Cross-talk regulation between cyclic AMP production and phosphoinositide hydrolysis induced by prostaglandin E2 in osteoblast-like cells.
Highly Cited
1990
Highly Cited
1990
T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway.
Highly Cited
1988
Highly Cited
1988
Receptor-mediated activation of electropermeabilized neutrophils. Evidence for a Ca2+- and protein kinase C-independent signaling pathway.
Highly Cited
1987
Highly Cited
1987
Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts
Diacylglycerol (DG) plays a central role in phospholipid metabolism and is an endogenous activator of protein kinase C (refs 1–3… 
Highly Cited
1986
Highly Cited
1986
Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.
Highly Cited
1985
Highly Cited
1985
A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters
The activation of protein kinase C by diacylglycerol and by tumour promoters has implicated this enzyme in transmembrane… 
Highly Cited
1985
Highly Cited
1985
Stimulation of 1,2-diacylglycerol accumulation in hepatocytes by vasopressin, epinephrine, and angiotensin II.
Highly Cited
1980
Highly Cited
1980
Specific high affinity cell membrane receptors for biologically active phorbol and ingenol esters
A variety of normal and transformed avian and mammalian cells and tissues contain high affinity specific receptors on their… 
Highly Cited
1977
Highly Cited
1977
Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.
Summary Topical application of retinoic acid to mouse skin led to a dramatic inhibition of phorbol ester (12- O -tetradecanoyl… 
Highly Cited
1977
Highly Cited
1977
The effect of phorbol diesters on chicken embryo fibroblasts.
Summary The tumor promoter phorbol myristate acetate (PMA) at concentrations of 1 to 30 ng/ml (1.5 to 45 × 10 −9 m) had dramatic… 
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