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Tetradecanoylphorbol Acetate

Known as: Myristate Acetate, Phorbol, Phorbol 13-Acetate, 12-O-Tetradecanoyl, PMA (phorbol myristate acetate) 
A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic… Expand
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (2)

12-O-tetradecanoylphorbol-1,3-acetatephorbolol myristate acetate

Broader (2)

CarcinogensPhorbols
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Protein kinase C: perfectly balanced
  • A. Newton
  • Critical reviews in biochemistry and molecular…
  • 2018
    • Corpus ID: 3716456
Abstract Protein kinase C (PKC) isozymes belong to a family of Ser/Thr kinases whose activity is governed by reversible release… Expand
Review
2003
Review
2003
Sphingosine-1-phosphate: an enigmatic signalling lipid
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals… Expand
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Highly Cited
1991
Highly Cited
1991
The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing.
Vascular endothelial growth factor (VEGF) is an apparently endothelial cell-specific mitogen that is structurally related to… Expand
Highly Cited
1989
Highly Cited
1989
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
We have identified and purified a novel cytokine, NK cell stimulatory factor (NKSF), from the cell-free supernatant fluid of the… Expand
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Highly Cited
1988
Highly Cited
1988
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.
The capacity of 12 cytokines to induce NO2- or H2O2 release from murine peritoneal macrophages was tested by using resident… Expand
Highly Cited
1988
Highly Cited
1988
Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate.
The effects of topically applied curcumin, chlorogenic acid, caffeic acid, and ferulic acid on 12-O-tetradecanoylphorbol-13… Expand
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Highly Cited
1987
Highly Cited
1987
Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor
The promoter regions of several phorbol diester-(TPA-) inducible genes (collagenase, stromelysin, hMT IIA, and SV40) share a… Expand
Highly Cited
1986
Highly Cited
1986
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
ICAM-1 is a cell surface glycoprotein originally defined by a monoclonal antibody (MAb) that inhibits phorbol ester-stimulated… Expand
Review
1984
Review
1984
The role of protein kinase C in cell surface signal transduction and tumour promotion
Protein kinase C has a crucial role in signal transduction for a variety of biologically active substances which activate… Expand
Highly Cited
1983
Highly Cited
1983
Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation
The production of a mouse monoclonal antibody, Ki‐67, is described. The Ki‐67 antibody recognized a nuclear antigen present in… Expand
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