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Tetradecanoylphorbol Acetate

Known as: Myristate Acetate, Phorbol, Phorbol 13-Acetate, 12-O-Tetradecanoyl, PMA (phorbol myristate acetate) 
A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (2)

12-O-tetradecanoylphorbol-1,3-acetatephorbolol myristate acetate

Broader (2)

CarcinogensPhorbols
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

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Highly Cited
1995
Highly Cited
1995
Identification of a gC1q-binding protein (gC1q-R) on the surface of human neutrophils. Subcellular localization and binding properties in comparison with the cC1q-R.
Human neutrophils have multiple C1q-binding proteins. Direct ligand-binding studies with the globular domain of C1q and two… 
Highly Cited
1987
Highly Cited
1987
Oligosaccharide Signaling In Plants
The in vitro phosphorylation by [yS2P]ATP of a 34kDa plasma membrane-associated protein (pp34) from tomato and potato is strongly… 
Highly Cited
1987
Highly Cited
1987
Neutrophils and mast cells. I. Human neutrophil-derived histamine-releasing activity.
Histamine release occurs during the late phase allergic reaction concomitantly with neutrophil (PMN) infiltration. To determine… 
Highly Cited
1986
Highly Cited
1986
The interleukin 2 secretion defect in vitro in systemic lupus erythematosus is reversible in rested cultured T cells.
Interleukin 2 (IL 2) secretion in response to mitogenic stimulation in vitro is strongly reduced in circulating T lymphocytes… 
Highly Cited
1986
Highly Cited
1986
Valency of CD3 binding and internalization of the CD3 cell-surface complex control T cell responses to second signals: distinction between effects on protein kinase C, cytoplasmic free calcium, and…
We have studied the relationship of valency of CD3 stimulation and modulation of the CD3 receptor complex with biochemical and… 
Highly Cited
1986
Highly Cited
1986
Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes.
Previous studies have implicated a role for protein kinase C (PKC) in transmembrane signal transduction by B cell surface… 
Highly Cited
1982
Highly Cited
1982
Acute and progressive lung injury after contact with phorbol myristate acetate.
Because of its potent ability to activate leukocytes and macrophages, resulting in the generation of large amounts of oxygen… 
Highly Cited
1977
Highly Cited
1977
Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.
Summary Topical application of retinoic acid to mouse skin led to a dramatic inhibition of phorbol ester (12- O -tetradecanoyl… 
Highly Cited
1977
Highly Cited
1977
Effect of phorbol myristate acetate on the recovery of spontaneous and ultraviolet light-induced 6-thioguanine and ouabain-resistant Chinese hamster cells.
12-0-Tetradecanoyl-phorbol-13-acetate (TPA) and phorbol were tested in Chinese hamster cells for their effects on mutagenesis… 
Highly Cited
1972
Highly Cited
1972
Early effects of 12-O-tetradecanoyl-phorbol-13-acetate on the incorporation of tritiated precursor into DNA and the thickness of the interfollicular epidermis, and their relation to tumor promotion…
The macroscopic and histological changes induced in mouse skin by various doses of 12- O -tetradecanoyl-phorbol-13-acetate (TPA…