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Phorbol Esters

Known as: Esters, Phorbol, Phorbol Ester, Phorbol Esters [Chemical/Ingredient] 
Polycyclic compound isolated from croton oil in which two hydroxyl groups on neighboring carbon atoms are esterified to fatty acids. The commonest of… 
National Institutes of Health

Related topics

Related topics

39 relations

Narrower (33)

12-O-benzyloxymethylphorbol-13-decanoate12-O-methoxymethylphorbol-13-decanoate12-O-retinoylphorbol-13-acetate12-deoxyphorbol 13-isobutyrate

Broader (2)

CarcinogensPhorbols
Croton Oilaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1993
Highly Cited
1993
Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells.
Highly Cited
1992
Highly Cited
1992
Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases.
Highly Cited
1992
Highly Cited
1992
Cross-talk regulation between cyclic AMP production and phosphoinositide hydrolysis induced by prostaglandin E2 in osteoblast-like cells.
Highly Cited
1990
Highly Cited
1990
Expression, purification, and characterization of protein kinase C-epsilon.
Review
1989
Review
1989
Modulation of protein kinase C and diverse cell functions by sphingosine--a pharmacologically interesting compound linking sphingolipids and signal transduction.
Highly Cited
1988
Highly Cited
1988
Suppression of nerve growth factor-directed neurite outgrowth in PC12 cells by sphingosine, an inhibitor of protein kinase C.
Highly Cited
1987
Highly Cited
1987
Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in ras-transformed fibroblasts
Diacylglycerol (DG) plays a central role in phospholipid metabolism and is an endogenous activator of protein kinase C (refs 1–3… 
Highly Cited
1986
Highly Cited
1986
Activation of protein kinase C induces rapid internalization and subsequent degradation of muscarinic acetylcholine receptors in neuroblastoma cells.
Highly Cited
1985
Highly Cited
1985
A model for intracellular translocation of protein kinase C involving synergism between Ca2+ and phorbol esters
The activation of protein kinase C by diacylglycerol and by tumour promoters has implicated this enzyme in transmembrane… 
Highly Cited
1977
Highly Cited
1977
Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoyl-phorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis.
Summary Topical application of retinoic acid to mouse skin led to a dramatic inhibition of phorbol ester (12- O -tetradecanoyl… 
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