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Phorbol

National Institutes of Health

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Phorbols

Narrower (1)

isophorbol

Papers overview

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2006
2006
Identification of potent, selective protein kinase C inhibitors based on a phorbol skeleton.
The elucidation of specific functions of protein kinase C (PKC) subtypes in physiological processes is an important challenge for… 
Highly Cited
2003
Highly Cited
2003
N-terminal Truncation of the Dopamine Transporter Abolishes Phorbol Ester- and Substance P Receptor-stimulated Phosphorylation without Impairing Transporter Internalization*
The structural basis of phosphorylation and its putative role in internalization were investigated in the human dopamine… 
2000
2000
GLAST: gene expression regulation by phorbol esters
The gene expression regulation of the Na+-dependent high affinity glutamate/aspartate transporter GLAST expressed in cultured… 
1999
1999
Intensification of growth factor receptor signalling by phorbol treatment of ligand-primed cells implies a dimer-stabilizing effect of protein kinase C-dependent juxtamembrane domain phosphorylation.
Highly Cited
1996
Highly Cited
1996
Transcriptional regulation of the human cholesterol 7 alpha-hydroxylase gene (CYP7A) in HepG2 cells.
A stable HepG2 cell line harboring a human cholesterol 7 alpha-hydroxylase (CYP7A) minigene/luciferase reporter gene construct… 
Highly Cited
1994
Highly Cited
1994
Inhibition of protein kinase C-alpha expression in human A549 cells by antisense oligonucleotides inhibits induction of intercellular adhesion molecule 1 (ICAM-1) mRNA by phorbol esters.
We have identified 20-mer phosphorothioate oligodeoxynucleotides which potently (IC50 values of 100-200 nM) and specifically… 
Highly Cited
1991
Highly Cited
1991
The AP-1 sequence is necessary but not sufficient for phorbol induction of collagenase in fibroblasts.
Collagenase, the only enzyme active at neutral pH that initiates collagen degradation, is a major gene product of fibroblasts… 
1991
1991
Phorbol diester-induced alterations in the expression of protein kinase C isozymes and their mRNAs. Analysis in wild-type and phorbol diester-resistant HL-60 cell clones.
Highly Cited
1990
Highly Cited
1990
Mutagenesis of the pseudosubstrate site of protein kinase C leads to activation.
Protein kinase C is maintained in an inactive state by the action of an inhibitory region within the effector binding domain of… 
Highly Cited
1986
Highly Cited
1986
Two different cis-active elements transfer the transcriptional effects of both EGF and phorbol esters.
Short cis-active sequences of the rat prolactin or Moloney murine leukemia virus genes transfer transcriptional regulation by… 
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