Pharmacogenetics

Known as: PGt, pharmacogenetic 
The study of how a person's genes affect the way he or she responds to drugs. Pharmacogenetics is being used to learn ahead of time what the best… (More)

Topic mentions per year

Topic mentions per year

1961-2017
020040019612017

Papers overview

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Highly Cited
2011
Highly Cited
2011
Thiopurine methyltransferase (TPMT) activity exhibits monogenic co-dominant inheritance, with ethnic differences in the frequency… (More)
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Highly Cited
2010
Highly Cited
2010
Warfarin-dosing algorithms incorporating CYP2C9 and VKORC1 -1639G>A improve dose prediction compared with algorithms based solely… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Genetic variability among patients plays an important role in determining the dose of warfarin that should be used… (More)
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Highly Cited
2008
Highly Cited
2008
Initiation of warfarin therapy using trial-and-error dosing is problematic. Our goal was to develop and validate a… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVES Efavirenz is an effective antiretroviral agent, but central nervous system side effects occur commonly, and population… (More)
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Highly Cited
2004
Highly Cited
2004
Knowledge of pharmacogenetics may help clinicians predict their patients' therapeutic dose of warfarin, thereby decreasing the… (More)
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Highly Cited
2002
Highly Cited
2002
The Pharmacogenetics Knowledge Base (PharmGKB; http://www.pharmgkb.org/) contains genomic, phenotype and clinical information… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND HIV-1-infected patients vary considerably by their response to antiretroviral treatment, drug concentrations in plasma… (More)
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Highly Cited
2001
Highly Cited
2001
Pharmacogenetics encompasses the involvement of genes in an individual's response to drugs. As such, the field covers a vast area… (More)
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Highly Cited
1996
Highly Cited
1996
Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA. A common genetic polymorphism… (More)
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