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Understanding the relationship between the primary structure of proteins and its propensity to be soluble on overexpression in Escherichia coli
- S. Idicula-Thomas, P. V. Balaji
- Chemistry, Medicine
- Protein science : a publication of the Protein…
- 1 March 2005
Solubility of proteins on overexpression in Escherichia coli is a manifestation of the net effect of several sequence‐dependent and sequence‐independent factors. This study aims to delineate the… Expand
Identification of linkage-specific sequence motifs in sialyltransferases.
Eukaryotic sialyltransferases (SiaTs) comprise a superfamily of enzymes catalyzing the transfer of sialic acid (Sia) from a common donor substrate to various acceptor substrates in different… Expand
Identification of common structural features of binding sites in galactose‐specific proteins
Galactose‐binding proteins characterize an important subgroup of sugar‐binding proteins that are involved in a variety of biological processes. Structural studies have shown that the Gal‐specific… Expand
Griseofulvin stabilizes microtubule dynamics, activates p53 and inhibits the proliferation of MCF-7 cells synergistically with vinblastine
- K. Rathinasamy, Bhavya Jindal, J. Asthana, P. Singh, P. V. Balaji, D. Panda
- Biology, Medicine
- BMC Cancer
- 19 May 2010
BackgroundGriseofulvin, an antifungal drug, has recently been shown to inhibit proliferation of various types of cancer cells and to inhibit tumor growth in athymic mice. Due to its low toxicity,… Expand
A support vector machine-based method for predicting the propensity of a protein to be soluble or to form inclusion body on overexpression in Escherichia coli
- S. Idicula-Thomas, Abhijit J. Kulkarni, B. Kulkarni, V. Jayaraman, P. V. Balaji
- Biology, Computer Science
- 1 February 2006
A support vector machine-based classifier to predict the solubility status of proteins on overexpression in E.coli based on the sequencebased features of these proteins. Expand
Mutational analysis of the Golgi retention signal of bovine beta-1,4-galactosyltransferase.
- A. Masibay, P. V. Balaji, E. Boeggeman, P. Qasba
- Biology, Medicine
- The Journal of biological chemistry
- 5 May 1993
To examine the role of the NH2-terminal region of the 402-residue-long beta-1,4-galactosyltransferase (beta-1,4-GT), a series of mutants and chimeric cDNA were constructed by polymerase chain… Expand
Crystal structure of beta1,4-galactosyltransferase complex with UDP-Gal reveals an oligosaccharide acceptor binding site.
The crystal structure of the catalytic domain of bovine beta1,4-galactosyltransferase (Gal-T1) co-crystallized with UDP-Gal and MnCl(2) has been solved at 2.8 A resolution. The structure not only… Expand
Comparative genomics analysis of completely sequenced microbial genomes reveals the ubiquity of N-linked glycosylation in prokaryotes.
Glycosylation of proteins in prokaryotes has been known for the last few decades. Glycan structures and/or the glycosylation pathways have been experimentally characterized in only a small number of… Expand
Crystal Structure Analysis of Beta 1,4-Galactosyltransferase Complex with UDP-galactose
Characterization of symmetric and asymmetric lipid bilayers composed of varying concentrations of ganglioside GM1 and DPPC.
Gangliosides are a group of structurally diverse, sialic acid containing glycosphingolipids embedded into the membrane via their hydrophobic ceramide moiety. To gain atomic level insights into the… Expand