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Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
- R. Mathijssen, R. V. van Alphen, A. Sparreboom
- BiologyClinical cancer research : an official journal of…
- 1 August 2001
CPT-11 belongs to the class of topoisomerase I inhibitors, and it acts as a prodrug of SN-38, which is approximately 100-1000-fold more cytotoxic than the parent drug. CPT-11 has shown a broad…
Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.
- H. Gelderblom, J. Verweij, K. Nooter, A. Sparreboom
- BiologyEuropean journal of cancer
- 1 September 2001
Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters
- Shuiying Hu, Zhaoyuan Chen, S. Baker
- Biology, ChemistryClinical Cancer Research
- 1 October 2009
TLDR
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.
- A. Sparreboom, J. van Asperen, O. van Tellingen
- Biology, MedicineProceedings of the National Academy of Sciences…
- 4 March 1997
TLDR
Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide
- E. Zimmerman, Shuiying Hu, S. Baker
- Biology, ChemistryClinical Cancer Research
- 22 January 2013
TLDR
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
- L. Treviño, N. Shimasaki, M. Relling
- Medicine, BiologyJournal of clinical oncology : official journal…
- 10 December 2009
TLDR
Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin‐Induced Nephrotoxicity
- K. Filipski, R. Mathijssen, T S Mikkelsen, A. Schinkel, A. Sparreboom
- BiologyClinical pharmacology and therapeutics
- 1 October 2009
TLDR
Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review
- M. Acharya, A. Sparreboom, J. Venitz, W. Figg
- BiologyMolecular Pharmacology
- 1 October 2005
TLDR
Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline.
- J. Griggs, P. Mangu, G. Lyman
- Medicine, BiologyJournal of clinical oncology : official journal…
- 1 May 2012
TLDR
Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel
- N. Smith, M. Acharya, N. Desai, William D. Figg, II, A. Sparreboom
- BiologyCancer biology & therapy
- 1 May 2005
TLDR
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