A. Sparreboom

Publications524
h-index93
Citations27,883
Highly Influential Citations985
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Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
CPT-11 belongs to the class of topoisomerase I inhibitors, and it acts as a prodrug of SN-38, which is approximately 100-1000-fold more cytotoxic than the parent drug. CPT-11 has shown a broad…
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Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation.
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Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters
TLDR
Unlike other tyrosine kinase inhibitors, sorafenib and sunitinib do not appear to rely on active transport to enter the cell nor are they high-affinity substrates for ABC efflux transporters, and may be less susceptible to transporter-mediated alterations in systemic exposure and transporter-related resistance mechanisms.
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Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.
TLDR
It is concluded that P-glycoprotein limits the oral uptake of paclitaxel and mediates direct excretion of the drug from the systemic circulation into the intestinal lumen.
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Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide
TLDR
Findings signify a unique role for OATP1B1 and OATp1B3 in the elimination of sorafenib-glucuronide and suggest a role for these transporters in the in vivo handling of glucuronic acid conjugates of drugs.
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Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
TLDR
A genome-wide interrogation identified inherited variations in a plausible, yet heretofore low-priority candidate gene, SLCO1B1, as important determinants of methotrexate's pharmacokinetics and clinical effects.
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Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin‐Induced Nephrotoxicity
TLDR
It is found that a nonsynonymous single‐nucleotide polymorphism (SNP) in the OCT2 gene SLC22A2 was associated with reduced cisplatin‐induced nephrotoxicity in patients and provides a rationale for the development of new targeted approaches to mitigate this debilitating side effect.
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Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review
TLDR
This review is an effort to summarize the nonclinical and clinical status of HDAC inhibitors currently under development in anticancer therapy.
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Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline.
TLDR
Full weight-based cytotoxic chemotherapy doses be used to treat obese patients with cancer, particularly when the goal of treatment is cure, and the use of fixed-dose chemotherapy is rarely justified.
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Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel
TLDR
Accumulation of [3H]docetaxel and [3h]paclitaxel in Xenopus laevis oocytes injected with cRNA of the liver-specific organic anion transporting polypeptide (OATP) family members OATP1B1 (OatP2) or OATp1B3 (O ATP8) is studied.
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