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Clinical pharmacokinetics and metabolism of irinotecan (CPT-11).
CPT-11 belongs to the class of topoisomerase I inhibitors, and it acts as a prodrug of SN-38, which is approximately 100-1000-fold more cytotoxic than the parent drug. CPT-11 has shown a broad
Interaction of the Multikinase Inhibitors Sorafenib and Sunitinib with Solute Carriers and ATP-Binding Cassette Transporters
TLDR
Unlike other tyrosine kinase inhibitors, sorafenib and sunitinib do not appear to rely on active transport to enter the cell nor are they high-affinity substrates for ABC efflux transporters, and may be less susceptible to transporter-mediated alterations in systemic exposure and transporter-related resistance mechanisms.
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.
TLDR
It is concluded that P-glycoprotein limits the oral uptake of paclitaxel and mediates direct excretion of the drug from the systemic circulation into the intestinal lumen.
Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide
TLDR
Findings signify a unique role for OATP1B1 and OATp1B3 in the elimination of sorafenib-glucuronide and suggest a role for these transporters in the in vivo handling of glucuronic acid conjugates of drugs.
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.
TLDR
A genome-wide interrogation identified inherited variations in a plausible, yet heretofore low-priority candidate gene, SLCO1B1, as important determinants of methotrexate's pharmacokinetics and clinical effects.
Contribution of Organic Cation Transporter 2 (OCT2) to Cisplatin‐Induced Nephrotoxicity
TLDR
It is found that a nonsynonymous single‐nucleotide polymorphism (SNP) in the OCT2 gene SLC22A2 was associated with reduced cisplatin‐induced nephrotoxicity in patients and provides a rationale for the development of new targeted approaches to mitigate this debilitating side effect.
Rational Development of Histone Deacetylase Inhibitors as Anticancer Agents: A Review
TLDR
This review is an effort to summarize the nonclinical and clinical status of HDAC inhibitors currently under development in anticancer therapy.
Appropriate chemotherapy dosing for obese adult patients with cancer: American Society of Clinical Oncology clinical practice guideline.
TLDR
Full weight-based cytotoxic chemotherapy doses be used to treat obese patients with cancer, particularly when the goal of treatment is cure, and the use of fixed-dose chemotherapy is rarely justified.
Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel
TLDR
Accumulation of [3H]docetaxel and [3h]paclitaxel in Xenopus laevis oocytes injected with cRNA of the liver-specific organic anion transporting polypeptide (OATP) family members OATP1B1 (OatP2) or OATp1B3 (O ATP8) is studied.
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