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Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
TLDR
Findings translate previous results from rat to humans and suggest a common effect of parental care on the epigenetic regulation of hippocampal glucocorticoid receptor expression.
View on Nature
Impaired Repression at a 5-Hydroxytryptamine 1A Receptor Gene Polymorphism Associated with Major Depression and Suicide
TLDR
The data indicate that NUDR is a repressor of the 5-HT1A receptor in raphe cells the function of which is abrogated by a promoter polymorphism, suggesting a novel transcriptional model in which the G(-1019) allele derepresses 5- HT1A autoreceptor expression to reduce serotonergic neurotransmission, predisposing to depression and suicide.
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Conserved Role of Intragenic DNA Methylation in Regulating Alternative Promoters
TLDR
An in-depth investigation of the human SHANK3 locus and its mouse homologue demonstrated that this tissue-specific DNA methylation regulates intragenic promoter activity in vitro and in vivo.
View on Nature
Suicide and suicidal behaviour
View on Elsevier
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
TLDR
A genome-wide association study found highly significant associations between RLS and intronic variants in the homeobox gene MEIS1, the BTBD9 gene encoding a BTB(POZ) domain as well as variants in a third locus containing the genes encoding mitogen-activated protein kinase MAP2K5 and the transcription factor LBXCOR1 on chromosomes 2p, 6p and 15q.
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Personality traits as correlates of suicidal ideation, suicide attempts, and suicide completions: a systematic review
TLDR
Concept background and empirical evidence investigating roles of traits in suicidal behaviors investigating involvement of personality traits in susceptibility to suicidality are reviewed.
View on Wiley
Analysis of shared heritability in common disorders of the brain
TLDR
It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
View on Science
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
TLDR
The largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 881 sentinel variants at loci with P<1×10-4, achieves genome- wide significance including 18 novel loci, which provide potential new biological mechanisms for bipolar disorder.
View on Springer
Suicide risk and prevention during the COVID-19 pandemic
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Psychiatric diagnoses in 3275 suicides: a meta-analysis
TLDR
Although psychopathology clearly mediates suicide risk, gender and geographical differences seem to exist in the relative proportion of the specific psychiatric disorders found among suicide completers.
View on Springer
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