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PSMB5 protein, human

Known as: PSX Large Multifunctional Protease X, Proteasome Epsilon Chain, Multicatalytic Endopeptidase Complex Epsilon Chain 
Proteasome subunit beta type-5 (263 aa, ~28 kDa) is encoded by the human PSMB5 gene. This protein plays a role in proteasomal protein degradation.
National Institutes of Health

Related topics

Related topics

13 relations
Antigen ProcessingApoptosisEndopeptidasesEnzyme Gene

Broader (1)

multicatalytic endopeptidase complex

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
Biogenesis of the 20S proteasome is tightly regulated. The N-terminal propeptides protecting the active-site threonines are… 
Highly Cited
2015
Highly Cited
2015
The Parkinson’s-associated protein DJ-1 regulates the 20S proteasome
The Parkinson’s-associated protein, DJ-1, is a highly conserved homodimer, ubiquitously expressed in cells. Here we demonstrate… 
Highly Cited
2013
Highly Cited
2013
A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster
SUMMARY In mammalian cells, hydrogen peroxide (H2O2)-induced adaptation to oxidative stress is strongly dependent on an Nrf2… 
Highly Cited
2012
Highly Cited
2012
A mutually inhibitory feedback loop between the 20S proteasome and its regulator, NQO1.
Highly Cited
2010
Highly Cited
2010
THE IMMUNOPROTEASOME, THE 20S PROTEASOME, AND THE PA28αβ PROTEASOME REGULATOR ARE OXIDATIVE STRESS‐ADAPTIVE PROTEOLYTIC COMPLEXES
We demonstrate the importance of various forms of the proteasome in adaptation to the oxidative stress of hydrogen peroxide (H2O2… 
Highly Cited
2010
Highly Cited
2010
Interactions of PAN's C‐termini with archaeal 20S proteasome and implications for the eukaryotic proteasome–ATPase interactions
Protein degradation in the 20S proteasome is regulated in eukaryotes by the 19S ATPase complex and in archaea by the homologous… 
Highly Cited
2008
Highly Cited
2008
A multimeric assembly factor controls the formation of alternative 20S proteasomes
The proteasome is the central regulatory protease of eukaryotic cells. Heteroheptameric α-subunit and β-subunit rings stack to… 
Highly Cited
1999
Highly Cited
1999
Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis.
Recent studies suggest that sepsis stimulates ubiquitin-dependent protein breakdown in skeletal muscle. In this proteolytic… 
Highly Cited
1997
Highly Cited
1997
Subunit arrangement in the human 20S proteasome.
In human 20S proteasomes two copies of each of seven different alpha-type and seven different beta-type subunits are assembled to… 
Highly Cited
1987
Highly Cited
1987
Pseudoexfoliative fibrillopathy in the conjunctiva. A relation to elastic fibers and elastosis.
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