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PSMB5 protein, human

Known as: PSX Large Multifunctional Protease X, Proteasome Epsilon Chain, Multicatalytic Endopeptidase Complex Epsilon Chain 
Proteasome subunit beta type-5 (263 aa, ~28 kDa) is encoded by the human PSMB5 gene. This protein plays a role in proteasomal protein degradation.
National Institutes of Health

Related topics

Related topics

13 relations
Antigen ProcessingApoptosisEndopeptidasesEnzyme Gene

Broader (1)

multicatalytic endopeptidase complex

Papers overview

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Highly Cited
2016
Highly Cited
2016
A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome
Biogenesis of the 20S proteasome is tightly regulated. The N-terminal propeptides protecting the active-site threonines are… 
Highly Cited
2015
Highly Cited
2015
The Parkinson's-associated protein DJ-1 regulates the 20S proteasome.
The Parkinson's-associated protein, DJ-1, is a highly conserved homodimer, ubiquitously expressed in cells. Here we demonstrate… 
Review
2014
Review
2014
Regulating the 20S Proteasome Ubiquitin-Independent Degradation Pathway
For many years, the ubiquitin-26S proteasome degradation pathway was considered the primary route for proteasomal degradation… 
Highly Cited
2013
Highly Cited
2013
A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster
SUMMARY In mammalian cells, hydrogen peroxide (H2O2)-induced adaptation to oxidative stress is strongly dependent on an Nrf2… 
Highly Cited
2010
Highly Cited
2010
THE IMMUNOPROTEASOME, THE 20S PROTEASOME, AND THE PA28αβ PROTEASOME REGULATOR ARE OXIDATIVE STRESS‐ADAPTIVE PROTEOLYTIC COMPLEXES
We demonstrate the importance of various forms of the proteasome in adaptation to the oxidative stress of hydrogen peroxide (H2O2… 
Highly Cited
2008
Highly Cited
2008
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases.
Highly Cited
2005
Highly Cited
2005
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.
Highly Cited
1999
Highly Cited
1999
Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis.
Recent studies suggest that sepsis stimulates ubiquitin-dependent protein breakdown in skeletal muscle. In this proteolytic… 
Highly Cited
1997
Highly Cited
1997
Subunit arrangement in the human 20S proteasome.
In human 20S proteasomes two copies of each of seven different alpha-type and seven different beta-type subunits are assembled to… 
Highly Cited
1996
Highly Cited
1996
Autocatalytic Subunit Processing Couples Active Site Formation in the 20S Proteasome to Completion of Assembly
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