PSMB5 protein, human

Known as: PSX Large Multifunctional Protease X, Proteasome Epsilon Chain, Multicatalytic Endopeptidase Complex Epsilon Chain 
Proteasome subunit beta type-5 (263 aa, ~28 kDa) is encoded by the human PSMB5 gene. This protein plays a role in proteasomal protein degradation.
National Institutes of Health

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13 relations
Antigen ProcessingApoptosisEndopeptidasesEnzyme Gene
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multicatalytic endopeptidase complex

Papers overview

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2015
2015
The Parkinson's-associated protein DJ-1 regulates the 20S proteasome.
The Parkinson's-associated protein, DJ-1, is a highly conserved homodimer, ubiquitously expressed in cells. Here we demonstrate… (More)
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Review
2014
Review
2014
Regulating the 20S Proteasome Ubiquitin-Independent Degradation Pathway
For many years, the ubiquitin-26S proteasome degradation pathway was considered the primary route for proteasomal degradation… (More)
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2011
2011
A Conserved 20S Proteasome Assembly Factor Requires a C-terminal HbYX Motif for Proteasomal Precursor Binding
Dedicated chaperones facilitate the assembly of the eukaryotic proteasome, but how they function remains largely unknown. Here we… (More)
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Highly Cited
2010
Highly Cited
2010
The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes.
Oxidized cytoplasmic and nuclear proteins are normally degraded by the proteasome, but accumulate with age and disease. We… (More)
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Highly Cited
2010
Highly Cited
2010
Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions.
Protein degradation in the 20S proteasome is regulated in eukaryotes by the 19S ATPase complex and in archaea by the homologous… (More)
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Highly Cited
2008
Highly Cited
2008
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases.
Substrates enter the cylindrical 20S proteasome through a gated channel that is regulated by the ATPases in the 19S regulatory… (More)
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Highly Cited
2008
Highly Cited
2008
A multimeric assembly factor controls the formation of alternative 20S proteasomes
The proteasome is the central regulatory protease of eukaryotic cells. Heteroheptameric α-subunit and β-subunit rings stack to… (More)
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Highly Cited
2005
Highly Cited
2005
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins.
The archaeal ATPase complex PAN, the homolog of the eukaryotic 26S proteasome-regulatory ATPases, was shown to associate… (More)
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Highly Cited
2000
Highly Cited
2000
Structural basis for the activation of 20S proteasomes by 11S regulators
Most of the non-lysosomal proteolysis that occurs in eukaryotic cells is performed by a nonspecific and abundant barrel-shaped… (More)
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1999
1999
Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis.
Recent studies suggest that sepsis stimulates ubiquitin-dependent protein breakdown in skeletal muscle. In this proteolytic… (More)
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