FAQ

multicatalytic endopeptidase complex

Known as: Prosome, Proteinase, Multicatalytic, Macropain 
Proteolytic complexes, proteolytic core of the proteasome system, that degrade cytosolic and nuclear proteins are implicated in ATP dependent… (More)

Topic mentions per year

Topic mentions per year

1981-2017
05010019812017

Related topics

Related topics

32 relations
20S core proteasome complex location26S proteasomeCell NucleusIn Blood
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Broader (1)

Cytoplasm

Narrower (7)

IngensinKi antigenLMP7 proteinPSMC1 gene
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
multicatalytic endopeptidase complex
Cell Nucleus
Cytoplasm
physiological aspects
Proteolysis
macromolecule

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Grain weight is one of the most important components of grain yield and is controlled by quantitative trait loci (QTLs) derived… (More)
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Highly Cited
2003
Highly Cited
2003
Quantitating protein synthesis, degradation, and endogenous antigen processing.
Using L929 cells, we quantitated the macroeconomics of protein synthesis and degradation and the microeconomics of producing MHC… (More)
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Highly Cited
2002
Highly Cited
2002
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome.
The 26S proteasome mediates degradation of ubiquitin-conjugated proteins. Although ubiquitin is recycled from proteasome… (More)
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Highly Cited
2002
Highly Cited
2002
Multiple associated proteins regulate proteasome structure and function.
We have identified proteins that are abundant in affinity-purified proteasomes, but absent from proteasomes as previously defined… (More)
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Highly Cited
2002
Highly Cited
2002
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues
Endoplasmic reticulum (ER) aminopeptidase 1 (ERAP1) appears to be specialized to produce peptides presented on class I major… (More)
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Highly Cited
2000
Highly Cited
2000
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.
MHC class I molecules function to present peptides eight to ten residues long to the immune system. These peptides originate… (More)
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Highly Cited
2000
Highly Cited
2000
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli.
To determine why proteasome inhibitors prevent thymocyte death, we examined whether proteasomes degrade anti-apoptotic molecules… (More)
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Highly Cited
1998
Highly Cited
1998
Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6.
The MDM2 oncoprotein targets the p53 tumor suppressor protein for degradation when the two proteins are expressed in cells. The… (More)
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Highly Cited
1995
Highly Cited
1995
A viral inhibitor of peptide transporters for antigen presentation.
Cytotoxic T lymphocytes lyse target cells after T-cell-receptor-mediated recognition of class I major histocompatibility complex… (More)
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Highly Cited
1994
Highly Cited
1994
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules.
Reagents that inhibit the ubiquitin-proteasome proteolytic pathway in cells have not been available. Peptide aldehydes that… (More)
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