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multicatalytic endopeptidase complex

Known as: Prosome, Proteinase, Multicatalytic, Macropain 
Proteolytic complexes, proteolytic core of the proteasome system, that degrade cytosolic and nuclear proteins are implicated in ATP dependent… Expand
National Institutes of Health

Related topics

Related topics

41 relations
20S core proteasome complex locationCell NucleusIn BloodMulticatalytic proteinase (complex) activity
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Narrower (18)

26S proteasome26S proteasome non-ATPase regulatory subunit 13Ki antigenLMP7 protein
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Broader (1)

Cytoplasm

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
A QTL for rice grain width and weight encodes a previously unknown RING-type E3 ubiquitin ligase
Grain weight is one of the most important components of grain yield and is controlled by quantitative trait loci (QTLs) derived… Expand
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Highly Cited
2005
Highly Cited
2005
A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ
Peroxisome proliferator-activated receptor-γ (PPAR-γ) has essential roles in adipogenesis and glucose homeostasis, and is a… Expand
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Highly Cited
2002
Highly Cited
2002
Control of β-Catenin Phosphorylation/Degradation by a Dual-Kinase Mechanism
Wnt regulation of beta-catenin degradation is essential for development and carcinogenesis. beta-catenin degradation is initiated… Expand
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Highly Cited
2001
Highly Cited
2001
CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin.
Complexes of the heat shock protein gp96 and antigenic peptides are taken up by antigen-presenting cells and presented by MHC… Expand
Review
2000
Review
2000
Aggresomes, inclusion bodies and protein aggregation.
  • R. Kopito
  • Trends in cell biology
  • 2000
    • Corpus ID: 24294639
Intracellular and extracellular accumulation of aggregated protein are linked to many diseases, including ageing-related… Expand
Highly Cited
2000
Highly Cited
2000
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes
MHC class I molecules function to present peptides eight to ten residues long to the immune system. These peptides originate… Expand
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Review
1998
Review
1998
Proteasome inhibitors: valuable new tools for cell biologists.
Proteasomes are major sites for protein degradation in eukaryotic cells. The recent identification of selective proteasome… Expand
Highly Cited
1997
Highly Cited
1997
β‐catenin is a target for the ubiquitin–proteasome pathway
β‐catenin is a central component of the cadherin cell adhesion complex and plays an essential role in the Wingless/Wnt signaling… Expand
Review
1996
Review
1996
Structure and functions of the 20S and 26S proteasomes.
The proteasome is an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells and is responsible for the… Expand
Highly Cited
1994
Highly Cited
1994
Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules
Reagents that inhibit the ubiquitin-proteasome proteolytic pathway in cells have not been available. Peptide aldehydes that… Expand
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