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multicatalytic endopeptidase complex

Known as: Prosome, Proteinase, Multicatalytic, Macropain 
Proteolytic complexes, proteolytic core of the proteasome system, that degrade cytosolic and nuclear proteins are implicated in ATP dependent… 
National Institutes of Health

Related topics

Related topics

41 relations
20S core proteasome complex locationCell NucleusIn BloodMulticatalytic proteinase (complex) activity

Narrower (18)

26S proteasome26S proteasome non-ATPase regulatory subunit 13Ki antigenLMP7 protein

Broader (1)

Cytoplasm

Papers overview

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Highly Cited
2004
Highly Cited
2004
Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins.
Most individuals with cystic fibrosis (CF) carry one or two mutations that result in a maturation defect of the full-length CFTR… 
Highly Cited
2003
Highly Cited
2003
PML Residue Lysine 160 Is Required for the Degradation of PML Induced by Herpes Simplex Virus Type 1 Regulatory Protein ICP0
ABSTRACT During the early stages of herpes simplex virus type 1 (HSV-1) infection, viral immediate-early regulatory protein ICP0… 
Review
2001
Review
2001
Implications of Protein Degradation in Aging
Abstract: Aging is characterized by accumulation of potentially harmful altered proteins that could lead to gradual deterioration… 
Highly Cited
1997
Highly Cited
1997
The generation of MHC class I-associated peptides is only partially inhibited by proteasome inhibitors: involvement of nonproteasomal cytosolic proteases in antigen processing?
The proteasome is believed to participate in the generation of a large percentage of peptide ligands for MHC class I molecules… 
Highly Cited
1997
Highly Cited
1997
Dissecting the assembly pathway of the 20S proteasome
Highly Cited
1995
Highly Cited
1995
The cleavage preference of the proteasome governs the yield of antigenic peptides
Proteasomes degrade endogenous proteins in the cytosol. The potential contribution of the proteasome to the effect of flanking… 
Highly Cited
1994
Highly Cited
1994
MHC-encoded proteasome subunits LMP2 and LMP7 are not required for efficient antigen presentation.
LMP2 and LMP7 are proteins encoded by MHC genes that are tightly linked to the genes encoding TAP, the transporter that conveys… 
Review
1993
Review
1993
Structural features of 26S and 20S proteasomes.
The 26S proteasome is the central protease of the ubiquitin-dependent pathway of protein degradation and has a highly conserved… 
Highly Cited
1992
Highly Cited
1992
Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits.
Highly Cited
1988
Highly Cited
1988
Electron microscopy and image analysis of the multicatalytic proteinase
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