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PSIP1 gene

Known as: PC4 and SFRS1 Interacting Protein 1 Gene, LENS EPITHELIUM-DERIVED GROWTH FACTOR, PSIP1 
This gene is involved in regulation of transcription. It also plays a role in mediation of pre-mRNA splicing.
National Institutes of Health

Related topics

Related topics

8 relations
Homo sapiensNFKB2 genePSIP1 protein, humanRNA Splicing

Narrower (1)

PSIP1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Design of HIV-1 integrase inhibitors targeting the catalytic domain as well as its interaction with LEDGF/p75: a scaffold hopping approach using salicylate and catechol groups.
Highly Cited
2010
Highly Cited
2010
The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering
Nearly all cellular and disease related functions of the transcriptional co-activator lens epithelium-derived growth factor… 
Highly Cited
2009
Highly Cited
2009
High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region
Lens epithelium-derived growth factor/p75 (LEDGF/p75) is a transcriptional coactivator involved in stress response, autoimmune… 
Highly Cited
2009
Highly Cited
2009
LEDGF/p75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors
LEDGF/p75 can tether over-expressed lentiviral integrase proteins to chromatin but how this underlies its integration cofactor… 
Highly Cited
2009
Highly Cited
2009
Affinities between the Binding Partners of the HIV-1 Integrase Dimer-Lens Epithelium-derived Growth Factor (IN Dimer-LEDGF) Complex
The interaction between lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF) and human immunodeficiency… 
Highly Cited
2007
Highly Cited
2007
Transcriptional Coactivator LEDGF/p75 Modulates Human Immunodeficiency Virus Type 1 Integrase-Mediated Concerted Integration
ABSTRACT Human transcriptional coactivator p75/lens epithelium-derived growth factor (LEDGF) binds human immunodeficiency virus… 
Highly Cited
2007
Highly Cited
2007
Structure-based mutagenesis of the integrase-LEDGF/p75 interface uncouples a strict correlation between in vitro protein binding and HIV-1 fitness.
2007
2007
LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the mechanism of viral cDNA integration.
2004
2004
Human Bcl-2 activates ERK signaling pathway to regulate activating protein-1, lens epithelium-derived growth factor and downstream genes
The proto-oncogene, bcl-2, has various functions besides its role in protecting cells from apoptosis. One of the functions is to… 
Highly Cited
2001
Highly Cited
2001
Humoral immune response directed against LEDGF in patients with VKH.
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